Cardinals vs Lions Prediction and Preview - NFL Week 5, 2026

The Arizona Cardinals will take on the favoured Detroit Lions in NFL Week 5 action at State Farm Stadium on Monday, October 12, beginning at 7:25am AEDT.

This article features Stats Insider's prediction and tips for the Cardinals vs Lions game, plus the latest betting odds in Australia.

Who Will Win?

Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Lions vs Cardinals 10,000 times.

Our independent predictive analytics model currently gives the Lions a 69% chance of beating the Cardinals in Week 5 of the NFL season.

Cardinals vs Lions: Odds

The latest Bet365 betting odds in Australia for this NFL game at State Farm Stadium are shown below:

• Head to Head: Cardinals $3.00, Lions $1.41
• Line: Cardinals +5.5 ($1.91), Lions -5.5 ($1.91)
• Total (Over/Under 52.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $3.00 and the Lions at $1.41.

The Cardinals are listed as 5.5-point underdogs against the Lions, with odds of $1.91 available at Bet365.

For the favourite Lions (-5.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 52.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the bookies have got it right and both the Cardinals and the Lions have a 50% chance of covering the line.

The 52.5-point over/under is expected to stay under 52% of the time.

Cardinals vs Lions: Best Bets

• Head to Head: Detroit at $1.41 with Bet365
• Line: Lions -5.5 at $1.91 with Bet365
• Total Points: Under 52.5 at $1.91 with Bet365

These Cardinals vs Lions best bets are based on world-class simulations and gambling experience to help you place better bets with your chosen online bookie.

Cardinals vs Lions: Prediction

Stats Insider's predicted final score for Cardinals vs Lions at State Farm Stadium in Week 5 is the Lions winning 28-23.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full coverage of the Arizona vs Detroit game in Week 5, including data-driven predictions and live win probabilitiestips.

Our model updates frequently, so refresh this page for the latest betting analysis before the Arizona vs Detroit match-up.

As always, see our Best Bets for the best tips for every NFL game, as well as predictions for a wide range of other sports.

Cardinals vs Lions: Week 5 Essential Details

The NFL Week 5 game between the Cardinals and Lions at State Farm Stadium is scheduled to start at 7:25am AEDT on Monday, October 12.

• Teams: Arizona Cardinals vs Detroit Lions
• Date: Monday 12 October 2026
• Time: 7:25am AEDT
• Venue: State Farm Stadium

All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.

Conclusion

Our Arizona vs Detroit predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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