Cardinals vs Giants Prediction and MLB Tips - 6 September 2025
Last updated: Sep 6, 2025, 12:15AM | Published: Sep 4, 2025, 7:32PM
The St. Louis Cardinals will take on the San Francisco Giants in MLB action at Busch Stadium on Saturday, beginning at 10:15am AEST.
Michael McGreevy (6-2, 4.17 ERA) will start for the Cardinals, while the Giants are going with Carson Seymour (0-2, 4.74 ERA).
This article features Stats Insider's prediction and tips for the Cardinals vs Giants game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the outcome of Saturday's St. Louis vs San Francisco MLB game 10,000 times.
Our independent predictive analytics model gives the Cardinals a 52% chance of winning against the Giants at Busch Stadium.
Cardinals vs Giants: Odds
The latest betting odds in Australia for Saturday's MLB game at Busch Stadium are listed below:
- Head to Head: Cardinals $1.83, Giants $2.00
- Line: Cardinals -1.5 ($2.75), Giants +1.5 ($1.48)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $1.83 and the Giants at $2.00.
The Cardinals are 1.5-run favourites against the Giants, with odds of $2.75 available at TAB.
For the underdog Giants (+1.5) to cover the line, TAB offers odds of $1.48.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Giants (+1.5) are predicted to cover the line 66% of the time, while the 8.5-run over/under is expected to stay under 53% of the time.
Cardinals vs Giants: Best Bets
- Head to Head: San Francisco at $2.00 with TAB
- Line: Giants +1.5 at $1.48 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Stats Insider's Cardinals vs Giants predictions are based on complex simulations and betting experience to help you place more informed bets with your chosen online bookie.
While the Cardinals have a higher chance of winning the game, betting on the Giants to win is our preferred option due to the edge found when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges seen on Stats Insider is crucial to being profitable in the long run.
Cardinals vs Giants: Prediction
Stats Insider provides full coverage of the St. Louis vs San Francisco game on Saturday, including data-driven predictions and free betting tips.
Remember, our model updates regularly, so bookmark this article for the latest betting analysis before the St. Louis vs San Francisco game.
As always, see Stats Insider's Best Bets to get the best tips on every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Giants: Essential Details
The game between the Cardinals and Giants at Busch Stadium is scheduled to begin at 10:15am AEST on Saturday.
- Teams: St. Louis Cardinals vs San Francisco Giants
- Date: Saturday 6 September 2025
- Time: 10:15am AEST
- Venue: Busch Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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