Cardinals vs Falcons Prediction and Preview - NFL Week 16, 2025
Last updated: Dec 15, 2025, 2:15AM | Published: Dec 14, 2025, 5:05AM
The Arizona Cardinals will take on the Atlanta Falcons in NFL Week 16 action at State Farm Stadium on Monday, December 22, beginning at 8:05am AEDT.
This article features Stats Insider's prediction and tips for the Cardinals vs Falcons game, along with the latest betting odds in Australia.
Who Will Win?
Using advanced machine learning and data, Stats Insider has simulated the result of Falcons vs Cardinals 10,000 times.
Our independent predictive analytics model currently gives the Cardinals a 57% chance of beating the Falcons at State Farm Stadium.
Cardinals vs Falcons: Odds
The latest Bet365 betting odds in Australia for this NFL game at State Farm Stadium are shown here:
- Head to Head: Cardinals $2.05, Falcons $1.80
- Line: Cardinals +1.5 ($1.91), Falcons -1.5 ($1.91)
- Total (Over/Under 45.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $2.05 and the Falcons at $1.80.
The Cardinals are listed as 1.5-point underdogs against the Falcons, with odds of $1.91 available at Bet365.
For the favourite Falcons (-1.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 45.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 58% of the time, while the 45.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Cardinals vs Falcons: Best Bets
- Head to Head: Arizona at $2.05 with Bet365
- Line: Cardinals +1.5 at $1.91 with Bet365
- Total Points: Under 45.5 at $1.91 with Bet365
When you see a 🔥, that means you've found one of Stats Insider's best bets for today across all sports.
Our Cardinals vs Falcons best bets are based on world-class simulations and betting experience to give you the best possible advice every time.
Cardinals vs Falcons: Prediction
Stats Insider's predicted final score for Cardinals vs Falcons at State Farm Stadium in Week 16 is the Cardinals winning 23-21.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Arizona vs Atlanta game in Week 16, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.Remember, our model updates regularly, so refresh this page for the latest betting predictions before the Arizona vs Atlanta game.
As always, see Stats Insider's Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
Cardinals vs Falcons: Week 16 Essential Details
The NFL Week 16 game between the Cardinals and Falcons at State Farm Stadium is scheduled to commence at 8:05am AEDT on Monday, December 22.
- Teams: Arizona Cardinals vs Atlanta Falcons
- Date: Monday 22 December 2025
- Time: 8:05am AEDT
- Venue: State Farm Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Arizona vs Atlanta predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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