Cardinals vs Cubs Prediction and MLB Tips - 27 June 2025
Last updated: Jun 26, 2025, 6:15PM | Published: Jun 25, 2025, 7:30PM
The St. Louis Cardinals will take on the Chicago Cubs in MLB action at Busch Stadium on Friday, commencing at 4:15am AEST.
The Cardinals will have Andre Pallante (5-3, 4.48 ERA) start, while the Cubs will counter with Shota Imanaga (3-2, 2.82 ERA).
This article features Stats Insider's free betting tips for the Cardinals vs Cubs game, plus the latest betting odds in Australia.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the result of Friday's St. Louis vs Cubs MLB match-up 10,000 times.
Our independent predictive analytics model gives the Cubs a 54% chance of beating the Cardinals at Busch Stadium.
Cardinals vs Cubs: Odds
The latest betting odds in Australia for Friday's MLB game at Busch Stadium are listed below:
- Head to Head: Cardinals $2.15, Cubs $1.74
- Line: Cardinals +1.5 ($1.72), Cubs -1.5 ($2.20)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $2.15 and the Cubs at $1.74.
The Cardinals are 1.5-run underdogs against the Cubs, with odds of $1.72 available at TAB.
For the favourite Cubs (-1.5) to cover the line, TAB offers odds of $2.20.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 59% of the time, while the 9-run over/under is expected to stay under 56% of the time.
Cardinals vs Cubs: Betting Tips
- Head to Head: St. Louis at $2.15 with TAB
- Line: Cardinals +1.5 at $1.72 with TAB
- Total Runs: Under 9 at $1.91 with TAB
Stats Insider's Cardinals vs Cubs betting tips are based on detailed simulations and gambling experience to bring you the best possible advice every time.
While the Cubs have a higher chance of winning the game, betting on the Cardinals to win is our recommended option because of the 1.6% edge found when comparing our data-driven probabilities to the odds currently available.
Taking advantage of the edges published on Stats Insider is crucial to being a profitable punter in the long run.
Cardinals vs Cubs: Prediction
Stats Insider provides full coverage of the St. Louis vs Cubs game on Friday, including data-driven predictions and computer tips.
Remember, our model updates regularly, so refresh this page for the latest betting predictions before the St. Louis vs Cubs game.
As always, see Stats Insider's Best Bets for betting tips on every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Cubs: Essential Details
The game between the Cardinals and Cubs at Busch Stadium is scheduled to start at 4:15am AEST on Friday.
- Teams: St. Louis Cardinals vs Chicago Cubs
- Date: Friday 27 June 2025
- Time: 4:15am AEST
- Venue: Busch Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs Cubs predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, tips for every MLB game, and futures probabilities for the MLB.
