Cardinals vs Brewers Prediction and MLB Tips - 22 September 2025
Last updated: Sep 21, 2025, 6:15PM | Published: Sep 21, 2025, 12:29AM
The St. Louis Cardinals will take on the Milwaukee Brewers in Game of the League Series at Busch Stadium on Monday, commencing at 4:15am AEST.
Matthew Liberatore (7-12, 4.30 ERA) will get the ball for the Cardinals, while the Brewers will counter with Robert Gasser (0-0, 0.00 ERA).
This article features Stats Insider's prediction and tips for the Cardinals vs Brewers game, along with the latest betting odds in Australia.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the result of Monday's St. Louis vs Milwaukee MLB game 10,000 times.
Our proven predictive analytics model currently gives the Brewers a 53% chance of beating the Cardinals at Busch Stadium.
Cardinals vs Brewers: Odds
The latest betting odds in Australia for Monday's MLB game at Busch Stadium are shown here:
- Head to Head: Cardinals $2.15, Brewers $1.74
- Line: Cardinals +1.5 ($1.67), Brewers -1.5 ($2.25)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $2.15 and the Brewers at $1.74.
The Cardinals are 1.5-run underdogs against the Brewers, with odds of $1.67 available at TAB.
For the favourite Brewers (-1.5) to cover the line, TAB offers odds of $2.25.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 61% of the time, while the 8.5-run over/under is expected to go over 51% of the time.
Cardinals vs Brewers: Best Bets
- Head to Head: St. Louis at $2.15 with TAB
- Line: Cardinals +1.5 at $1.67 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
These Cardinals vs Brewers betting tips are based on world-class modelling and betting experience to help you place more informed bets with your chosen online bookie.
While the Brewers have a higher chance of winning the game, betting on the Cardinals to win is our recommended option due to the 2.6% edge identified when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges published here at Stats Insider is crucial to achieving long-term profitability.
Cardinals vs Brewers: Prediction
Stats Insider provides full betting coverage of the St. Louis vs Milwaukee game on Monday, including data-driven predictions and the best betting tips.
Our model updates frequently, so bookmark this article for the latest betting predictions before the St. Louis vs Milwaukee game.
As always, see Stats Insider's Best Bets to get the best tips on every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Brewers: Essential Details
The match-up between the Cardinals and Brewers at Busch Stadium is scheduled to start at 4:15am AEST on Monday.
- Teams: St. Louis Cardinals vs Milwaukee Brewers
- Date: Monday 22 September 2025
- Time: 4:15am AEST
- Venue: Busch Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs Milwaukee predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's vital to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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