Cardinals vs Brewers Prediction and MLB Tips - 21 September 2025
Last updated: Sep 20, 2025, 11:11PM | Published: Sep 19, 2025, 7:32PM
The St. Louis Cardinals will sqaure off with the Milwaukee Brewers in Game of the League Series at Busch Stadium on Sunday, starting at 9:15am AEST.
The Cardinals will have Miles Mikolas (8-10, 4.80 ERA) start, while the Brewers are going with Chad Patrick (3-8, 3.64 ERA).
This article features Stats Insider's top betting tips for the Cardinals vs Brewers game, as well as the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the outcome of Sunday's St. Louis vs Milwaukee MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Brewers a 54% chance of winning against the Cardinals at Busch Stadium.
Cardinals vs Brewers: Odds
The current betting odds in Australia for Sunday's MLB game at Busch Stadium are listed below:
- Head to Head: Cardinals $2.20, Brewers $1.71
- Line: Cardinals +1.5 ($1.74), Brewers -1.5 ($2.14)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $2.20 and the Brewers at $1.71.
The Cardinals are 1.5-run underdogs against the Brewers, with odds of $1.74 available at TAB.
For the favourite Brewers (-1.5) to cover the line, TAB offers odds of $2.14.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 58% of the time, while the 8.5-run over/under is expected to go over 54% of the time.
Cardinals vs Brewers: Best Bets
- Head to Head: St. Louis at $2.20 with TAB
- Line: Cardinals +1.5 at $1.74 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
These Cardinals vs Brewers betting tips are based on complex simulations and betting expertise to provide you with the best possible advice around the clock.
While the Brewers have a higher chance of winning the game, betting on the Cardinals to win is our recommended option due to the 2.1% edge found when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges seen on Stats Insider is crucial to being a profitable punter in the long run.
Cardinals vs Brewers: Prediction
Stats Insider provides full coverage of the St. Louis vs Milwaukee game on Sunday, including data-driven predictions and the best betting tips.
Our model updates frequently, so keep checking this page for the latest betting predictions before the St. Louis vs Milwaukee match-up.
As always, see our Best Bets to get the best tips on every MLB game, as well as predictions for a wide range of other sports.
Cardinals vs Brewers: Essential Details
The match-up between the Cardinals and Brewers at Busch Stadium is scheduled to begin at 9:15am AEST on Sunday.
- Teams: St. Louis Cardinals vs Milwaukee Brewers
- Date: Sunday 21 September 2025
- Time: 9:15am AEST
- Venue: Busch Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs Milwaukee predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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