Cardinals vs Brewers Prediction and MLB Tips - 20 September 2025
Last updated: Sep 20, 2025, 12:12AM | Published: Sep 18, 2025, 7:31PM
The St. Louis Cardinals will face the Milwaukee Brewers in MLB action at Busch Stadium on Saturday, starting at 10:15am AEST.
The Cardinals will have Sonny Gray (13-8, 4.43 ERA) start, pitting him against Jacob Misiorowski (5-2, 4.35 ERA) for the Brewers.
This article features Stats Insider's best betting tips for the Cardinals vs Brewers game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the result of Saturday's St. Louis vs Milwaukee MLB game 10,000 times.
Our independent predictive analytics model gives the Brewers a 51% chance of beating the Cardinals at Busch Stadium.
Cardinals vs Brewers: Odds
The current betting odds in Australia for Saturday's MLB game at Busch Stadium are shown below:
- Head to Head: Cardinals $2.05, Brewers $1.80
- Line: Cardinals +1.5 ($1.61), Brewers -1.5 ($2.40)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $2.05 and the Brewers at $1.80.
The Cardinals are 1.5-run underdogs against the Brewers, with odds of $1.61 available at TAB.
For the favourite Brewers (-1.5) to cover the line, TAB offers odds of $2.40.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Cardinals (+1.5) are predicted to cover the line 63% of the time, while the 7.5-run over/under is expected to go over 52% of the time.
Cardinals vs Brewers: Best Bets
- Head to Head: St. Louis at $2.05 with TAB
- Line: Cardinals +1.5 at $1.61 with TAB
- Total Runs: Over 7.5 at $1.91 with TAB
Stats Insider's Cardinals vs Brewers predictions are based on world-class simulations and gambling intelligence to bring you the best possible advice 24/7/365.
While the Brewers have a higher chance of winning the game, betting on the Cardinals to win is our preferred option due to the 2.0% edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges published here at Stats Insider is one of the keys to being a profitable sports bettor in the long run.
Cardinals vs Brewers: Prediction
Stats Insider provides full coverage of the St. Louis vs Milwaukee game on Saturday, including data-driven predictions and top betting tips.
Remember, our model updates frequently, so refresh this page for the latest betting tips before the St. Louis vs Milwaukee match-up.
As always, see Stats Insider's Best Bets for the best tips on every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Brewers: Essential Details
The game between the Cardinals and Brewers at Busch Stadium is scheduled to begin at 10:15am AEST on Saturday.
- Teams: St. Louis Cardinals vs Milwaukee Brewers
- Date: Saturday 20 September 2025
- Time: 10:15am AEST
- Venue: Busch Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs Milwaukee predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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