Cardinals vs 49ers Prediction and Preview - NFL Week 11, 2025
Last updated: Nov 9, 2025, 7:56AM | Published: Nov 9, 2025, 5:01AM
The Arizona Cardinals will sqaure off with the San Francisco 49ers in NFL Week 11 action at State Farm Stadium on Monday, November 17, commencing at 8:05am AEDT.
This article features Stats Insider's prediction and tips for the Cardinals vs 49ers game, as well as the latest betting odds in Australia.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the result of 49ers vs Cardinals 10,000 times.
Our leading predictive analytics model gives the 49ers a 58% chance of winning against the Cardinals in Week 11 of the NFL season.
Cardinals vs 49ers: Odds
The latest Bet365 betting odds in Australia for this NFL game at State Farm Stadium are listed here:
- Head to Head: Cardinals $2.05, 49ers $1.80
- Line: Cardinals +1.5 ($1.91), 49ers -1.5 ($1.91)
- Total (Over/Under 47.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $2.05 and the 49ers at $1.80.
The Cardinals are 1.5-point underdogs against the 49ers, with odds of $1.91 available at Bet365.
For the favourite 49ers (-1.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the 49ers (-1.5) are predicted to cover the line 53% of the time, while the 47.5-point over/under is expected to stay under 56% of the time.
Cardinals vs 49ers: Best Bets
- Head to Head: San Francisco at $1.80 with Bet365
- Line: 49ers -1.5 at $1.91 with Bet365
- Total Points: Under 47.5 at $1.91 with Bet365
Stats Insider's Cardinals vs 49ers best bets are based on detailed simulations and gambling expertise to provide you with the best possible advice 24/7.
Cardinals vs 49ers: Prediction
Stats Insider's predicted final score for Cardinals vs 49ers at State Farm Stadium in Week 11 is the 49ers winning 23-21.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the Arizona vs San Francisco game in Week 11, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.Remember, our model updates frequently, so keep checking this article for the latest betting predictions before the Arizona vs San Francisco game.
As always, see our Best Bets for betting tips for every NFL game, plus predictions for a wide range of other sports.
Cardinals vs 49ers: Week 11 Essential Details
The NFL Week 11 match-up between the Cardinals and 49ers at State Farm Stadium is scheduled to commence at 8:05am AEDT on Monday, November 17.
- Teams: Arizona Cardinals vs San Francisco 49ers
- Date: Monday 17 November 2025
- Time: 8:05am AEDT
- Venue: State Farm Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Arizona vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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