Cardinals vs 49ers Prediction and Preview - NFL Week 11, 2025
Last updated: Nov 16, 2025, 9:05PM | Published: Nov 9, 2025, 5:01AM
The Arizona Cardinals will take on the San Francisco 49ers in NFL Week 11 action at State Farm Stadium on Monday, beginning at 8:05am AEDT.
This article features Stats Insider's prediction and tips for the Cardinals vs 49ers game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Arizona vs San Francisco NFL match-up 10,000 times.
Our independent predictive analytics model currently gives the 49ers a 60% chance of defeating the Cardinals in Week 11 of the NFL season.
Cardinals vs 49ers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at State Farm Stadium are shown here:
- Head to Head: Cardinals $2.60, 49ers $1.53
- Line: Cardinals +3.5 ($1.91), 49ers -3.5 ($1.91)
- Total (Over/Under 48.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $2.60 and the 49ers at $1.53.
The Cardinals are 3.5-point underdogs against the 49ers, with odds of $1.91 available at Bet365.
For the favourite 49ers (-3.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Cardinals (+3.5) are predicted to cover the line 59% of the time, while the 48.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Cardinals vs 49ers: Betting Tips
- Head to Head: Arizona at $2.60 with Bet365
- Line: Cardinals +3.5 at $1.91 with Bet365
- Total Points: Under 48.5 at $1.91 with Bet365
When you see a 🔥, you know you've found one of Stats Insider's best tips for today across any sport.
Our Cardinals vs 49ers predictions are based on world-class modelling and wagering experience to provide you with the best possible advice around the clock.
While the 49ers have a higher chance of winning the game, betting on the Cardinals to win is our recommended option because of the 2.0% edge identified when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is pivotal to achieving long-term success as a punter.
Cardinals vs 49ers: Prediction
Stats Insider's predicted final score for Cardinals vs 49ers at State Farm Stadium in Week 11 is the 49ers winning 25-22.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Arizona vs San Francisco game in Week 11, including data-driven predictions and live scorestips.
Get expert analysis from the US with Dimers' in-depth Cardinals vs 49ers prediction.
18+. Odds correct at time of publishing and subject to change.Cardinals vs 49ers: TD Scorer Tips
Who will score the first touchdown in Cardinals vs 49ers? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in Cardinals vs 49ers.
McCaffrey has a 17.5% chance of scoring the first TD at State Farm Stadium, while the 49ers RB has a 63.8% chance of scoring an anytime touchdown.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Cardinals First TD Tips
- Trey McBride: 10.0% probability
- Bam Knight: 8.5% probability
- Emari Demercado: 5.5% probability
- Michael Wilson: 5.4% probability
- Greg Dortch: 4.6% probability
49ers First TD Tips
- Christian McCaffrey: 17.5% probability
- George Kittle: 8.0% probability
- Jauan Jennings: 6.0% probability
- Ricky Pearsall: 5.4% probability
- Brian Robinson: 3.1% probability
Anytime Touchdown Scorer Tips
Cardinals Anytime TD Tips
- Trey McBride: 43.9% probability
- Bam Knight: 38.8% probability
- Emari Demercado: 27.0% probability
- Michael Wilson: 26.7% probability
- Greg Dortch: 23.5% probability
49ers Anytime TD Tips
- Christian McCaffrey: 63.8% probability
- George Kittle: 37.1% probability
- Jauan Jennings: 29.4% probability
- Ricky Pearsall: 26.9% probability
- Brian Robinson: 16.7% probability
Cardinals-49ers Projected Player Stats
Of the starting quarterbacks, the Cardinals' Jacoby Brissett is projected for 233 passing yards, while the 49ers' Brock Purdy is expected to throw for 256 yards.
Cardinals Starting QB
- Jacoby Brissett: 233 projected passing yards
49ers Starting QB
- Brock Purdy: 256 projected passing yards
Cardinals Rushing Yards
- Bam Knight: 44 projected yards
- Emari Demercado: 41 projected yards
- Jacoby Brissett: 20 projected yards
49ers Rushing Yards
- Christian McCaffrey: 75 projected yards
- Brian Robinson: 24 projected yards
- Brock Purdy: 13 projected yards
Cardinals Receiving Yards
- Trey McBride: 74 projected yards
- Michael Wilson: 51 projected yards
- Greg Dortch: 34 projected yards
- Elijah Higgins: 16 projected yards
- Xavier Weaver: 12 projected yards
49ers Receiving Yards
- Jauan Jennings: 54 projected yards
- George Kittle: 54 projected yards
- Christian McCaffrey: 50 projected yards
- Ricky Pearsall: 46 projected yards
- Kendrick Bourne: 16 projected yards
Remember, our model updates frequently, so refresh this article for the latest betting tips before the Arizona vs San Francisco game.
As always, see Stats Insider's Best Bets to get betting tips on every NFL game, as well as predictions for a wide range of other sports.
Cardinals vs 49ers: Week 11 Essential Details
The NFL Week 11 match-up between the Cardinals and 49ers at State Farm Stadium is scheduled to begin at 8:05am AEDT on Monday.
- Teams: Arizona Cardinals vs San Francisco 49ers
- Date: Monday 17 November 2025
- Time: 8:05am AEDT
- Venue: State Farm Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Arizona vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's important that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on NFL
Stats Insider is your go-to source for betting on the NFL in Australia, with the latest NFL betting news, predictions for every NFL game, and Super Bowl odds for the NFL.
