Buccaneers vs 49ers Prediction and Preview - NFL Week 6, 2025
Last updated: Oct 12, 2025, 8:25PM | Published: Oct 7, 2025, 12:51AM
The Tampa Bay Buccaneers will sqaure off with the San Francisco 49ers in NFL Week 6 action at Raymond James Stadium on Monday, beginning at 7:25am AEDT.
This article features Stats Insider's best betting tips for the Buccaneers vs 49ers game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the outcome of Monday's Tampa Bay vs San Francisco NFL game 10,000 times.
Our proven predictive analytics model currently gives the Buccaneers a 61% chance of beating the 49ers in Week 6 of the NFL season.
Buccaneers vs 49ers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Raymond James Stadium are listed below:
- Head to Head: Buccaneers $1.53, 49ers $2.60
- Line: Buccaneers -3.5 ($1.91), 49ers +3.5 ($1.91)
- Total (Over/Under 47 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Buccaneers at $1.53 and the 49ers at $2.60.
The Buccaneers are listed as 3.5-point favourites against the 49ers, with odds of $1.91 available at Bet365.
For the underdog 49ers (+3.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the Buccaneers and the 49ers have a 50% chance of covering the line.
The 47-point over/under is expected to stay under 52% of the time.
Buccaneers vs 49ers: Best Bets
- Head to Head: San Francisco at $2.60 with Bet365
- Line: 49ers +3.5 at $1.91 with Bet365
- Total Points: Under 47 at $1.91 with Bet365
These Buccaneers vs 49ers best bets are based on detailed modelling and wagering expertise to give you the best possible advice 24/7/365.
While the Buccaneers have a higher chance of winning the game, betting on the 49ers to win is our recommended option due to the edge found when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges published on Stats Insider is crucial to being a profitable sports bettor in the long run.
Buccaneers vs 49ers: Prediction
Stats Insider's predicted final score for Buccaneers vs 49ers at Raymond James Stadium in Week 6 is the Buccaneers winning 24-21.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Tampa Bay vs San Francisco game in Week 6, including data-driven predictions and free tips.
For in-depth analysis from US experts,, check out Dimers' detailed Buccaneers vs 49ers prediction.
18+. Odds correct at time of publishing and subject to change.Buccaneers vs 49ers: TD Scorer Tips
Who will score the first touchdown in Buccaneers vs 49ers? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in Buccaneers vs 49ers.
McCaffrey has a 14.1% chance of scoring the first TD at Raymond James Stadium, while the 49ers RB has a 56.2% chance of scoring an anytime touchdown.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Buccaneers First TD Tips
- Rachaad White: 14.0% probability
- Emeka Egbuka: 11.4% probability
- Cade Otton: 5.2% probability
- Sterling Shepard: 5.2% probability
- Sean Tucker: 4.5% probability
49ers First TD Tips
- Christian McCaffrey: 14.1% probability
- Jauan Jennings: 6.2% probability
- Kendrick Bourne: 5.1% probability
- Jake Tonges: 4.8% probability
- Demarcus Robinson: 3.3% probability
Anytime Touchdown Scorer Tips
Buccaneers Anytime TD Tips
- Rachaad White: 53.3% probability
- Emeka Egbuka: 46.2% probability
- Cade Otton: 24.6% probability
- Sterling Shepard: 24.5% probability
- Sean Tucker: 21.7% probability
49ers Anytime TD Tips
- Christian McCaffrey: 56.2% probability
- Jauan Jennings: 30.2% probability
- Kendrick Bourne: 25.7% probability
- Jake Tonges: 24.4% probability
- Demarcus Robinson: 17.6% probability
Buccaneers-49ers Projected Player Stats
Of the starting quarterbacks, the Buccaneers' Baker Mayfield is projected for 251 passing yards. The 49ers' Mac Jones is expected to throw for 248 yards.
Buccaneers Starting QB
- Baker Mayfield: 251 projected passing yards
49ers Starting QB
- Mac Jones: 248 projected passing yards
Buccaneers Rushing Yards
- Rachaad White: 67 projected yards
- Baker Mayfield: 23 projected yards
- Sean Tucker: 21 projected yards
49ers Rushing Yards
- Christian McCaffrey: 66 projected yards
- Brian Robinson: 19 projected yards
- Mac Jones: 9 projected yards
Buccaneers Receiving Yards
- Emeka Egbuka: 80 projected yards
- Sterling Shepard: 39 projected yards
- Tez Johnson: 38 projected yards
- Cade Otton: 36 projected yards
- Rachaad White: 28 projected yards
49ers Receiving Yards
- Jauan Jennings: 56 projected yards
- Christian McCaffrey: 51 projected yards
- Kendrick Bourne: 50 projected yards
- Jake Tonges: 36 projected yards
- Demarcus Robinson: 27 projected yards
Our model updates regularly, so bookmark this article for the latest betting tips before the Tampa Bay vs San Francisco game.
As always, see Stats Insider's Best Bets to get the best tips on every NFL game, plus predictions for a wide range of other sports.
Buccaneers vs 49ers: Week 6 Essential Details
The NFL Week 6 game between the Buccaneers and 49ers at Raymond James Stadium is scheduled to start at 7:25am AEDT on Monday.
- Teams: Tampa Bay Buccaneers vs San Francisco 49ers
- Date: Monday 13 October 2025
- Time: 7:25am AEDT
- Venue: Raymond James Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Tampa Bay vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you decide to use our NFL predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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