Buccaneers vs 49ers Prediction and Preview - NFL Week 6, 2025
Last updated: Oct 10, 2025, 8:05PM | Published: Oct 7, 2025, 12:51AM
The Tampa Bay Buccaneers will face the San Francisco 49ers in NFL Week 6 action at Raymond James Stadium on Monday, commencing at 7:25am AEDT.
This article features Stats Insider's prediction and tips for the Buccaneers vs 49ers game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Using trusted computer power and data, Stats Insider has simulated the outcome of Monday's Tampa Bay vs San Francisco NFL game 10,000 times.
Our independent predictive analytics model currently gives the Buccaneers a 59% chance of defeating the 49ers at Raymond James Stadium.
Buccaneers vs 49ers: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Raymond James Stadium are listed here:
- Head to Head: Buccaneers $1.62, 49ers $2.35
- Line: Buccaneers -3 ($1.91), 49ers +3 ($1.91)
- Total (Over/Under 47.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Buccaneers at $1.62 and the 49ers at $2.35.
The Buccaneers are 3-point favourites against the 49ers, with odds of $1.91 available at Bet365.
For the underdog 49ers (+3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookies have got it right and both the Buccaneers and the 49ers have a 50% chance of covering the line.
The 47.5-point over/under is expected to stay under 54% of the time.
Buccaneers vs 49ers: Best Bets
- Head to Head: San Francisco at $2.35 with Bet365
- Line: 49ers +3 at $1.91 with Bet365
- Total Points: Under 47.5 at $1.91 with Bet365
Our Buccaneers vs 49ers betting tips are based on market-leading modelling and wagering intelligence to help you place more informed bets with your chosen online bookie.
While the Buccaneers have a higher chance of winning the game, betting on the 49ers to win is our preferred option because of the edge found when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges published here at Stats Insider is one of the keys to achieving long-term profitability.
Buccaneers vs 49ers: Prediction
Stats Insider's predicted final score for Buccaneers vs 49ers at Raymond James Stadium in Week 6 is the Buccaneers winning 24-22.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Tampa Bay vs San Francisco game in Week 6, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.Buccaneers vs 49ers: TD Scorer Tips
Who will score the first touchdown in Buccaneers vs 49ers? The latest data is in.
According to Stats Insider, Tampa Bay's Rachaad White is the most likely player to score the first TD in Buccaneers vs 49ers.
White has a 14.7% chance of getting in for six first at Raymond James Stadium, while the Buccaneers RB has a 53.2% chance of reaching the end zone at any point during the game.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Buccaneers First TD Tips
- Rachaad White: 14.7% probability
- Emeka Egbuka: 11.8% probability
- Sterling Shepard: 5.6% probability
- Cade Otton: 5.2% probability
- Sean Tucker: 4.5% probability
49ers First TD Tips
- Christian McCaffrey: 12.4% probability
- Ricky Pearsall: 5.3% probability
- Jauan Jennings: 5.2% probability
- Kendrick Bourne: 4.4% probability
- Jake Tonges: 4.3% probability
Anytime Touchdown Scorer Tips
Buccaneers Anytime TD Tips
- Rachaad White: 53.2% probability
- Emeka Egbuka: 45.7% probability
- Sterling Shepard: 25.2% probability
- Cade Otton: 23.5% probability
- Sean Tucker: 20.9% probability
49ers Anytime TD Tips
- Christian McCaffrey: 57.5% probability
- Ricky Pearsall: 30.6% probability
- Jauan Jennings: 30.0% probability
- Kendrick Bourne: 25.9% probability
- Jake Tonges: 25.8% probability
Buccaneers-49ers Projected Player Stats
Of the starting quarterbacks, the Buccaneers' Baker Mayfield is projected for 251 passing yards, while the 49ers' Mac Jones is expected to throw for 248 yards.
Buccaneers Starting QB
- Baker Mayfield: 251 projected passing yards
49ers Starting QB
- Mac Jones: 248 projected passing yards
Buccaneers Rushing Yards
- Rachaad White: 60 projected yards
- Sean Tucker: 21 projected yards
- Baker Mayfield: 19 projected yards
49ers Rushing Yards
- Christian McCaffrey: 69 projected yards
- Brian Robinson: 15 projected yards
- Mac Jones: 13 projected yards
Buccaneers Receiving Yards
- Emeka Egbuka: 85 projected yards
- Sterling Shepard: 40 projected yards
- Tez Johnson: 38 projected yards
- Cade Otton: 31 projected yards
- Rachaad White: 28 projected yards
49ers Receiving Yards
- Christian McCaffrey: 49 projected yards
- Ricky Pearsall: 45 projected yards
- Jauan Jennings: 45 projected yards
- Jake Tonges: 38 projected yards
- Kendrick Bourne: 30 projected yards
Our model updates regularly, so bookmark this page for the latest betting analysis before the Tampa Bay vs San Francisco game.
As always, see our Best Bets for betting tips for every NFL game, plus predictions for a wide range of other sports.
Buccaneers vs 49ers: Week 6 Essential Details
The NFL Week 6 match-up between the Buccaneers and 49ers at Raymond James Stadium is scheduled to start at 7:25am AEDT on Monday.
- Teams: Tampa Bay Buccaneers vs San Francisco 49ers
- Date: Monday 13 October 2025
- Time: 7:25am AEDT
- Venue: Raymond James Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Tampa Bay vs San Francisco predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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