Browns vs Bills Prediction and Preview - NFL Week 16, 2025
Last updated: Dec 21, 2025, 6:01PM | Published: Dec 14, 2025, 5:01AM
The Cleveland Browns will sqaure off with the favoured Buffalo Bills in NFL Week 16 action at Huntington Bank Field on Monday, commencing at 5:00am AEDT.
This article features Stats Insider's prediction and tips for the Browns vs Bills game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the outcome of Monday's Cleveland vs Buffalo NFL match-up 10,000 times.
Our independent predictive analytics model gives the Bills an 85% chance of defeating the Browns in Week 16 of the NFL season.
Browns vs Bills: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Huntington Bank Field are listed here:
- Head to Head: Browns $5.25, Bills $1.17
- Line: Browns +10.5 ($1.91), Bills -10.5 ($1.91)
- Total (Over/Under 41 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Browns at $5.25 and the Bills at $1.17.
The Browns are listed as 10.5-point underdogs against the Bills, with odds of $1.91 available at Bet365.
For the favourite Bills (-10.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 41 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the Browns and the Bills have a 50% chance of covering the line.
The 41-point over/under is expected to go over 52% of the time.
Browns vs Bills: Betting Tips
- Head to Head: Buffalo at $1.17 with Bet365
- Line: Bills -10.5 at $1.91 with Bet365
- Total Points: Over 41 at $1.91 with Bet365
These Browns vs Bills betting tips are based on complex simulations and betting intelligence to help you place smarter bets with your chosen online bookie.
Browns vs Bills: Prediction
Stats Insider's predicted final score for Browns vs Bills at Huntington Bank Field in Week 16 is the Bills winning 25-15.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the Cleveland vs Buffalo game in Week 16, including data-driven predictions and live scorestips.
Get expert analysis from the US with Dimers' in-depth Browns vs Bills prediction.
18+. Odds correct at time of publishing and subject to change.Browns vs Bills: TD Scorer Tips
Who will score the first touchdown in Browns vs Bills? The latest data is in.
According to Stats Insider, Buffalo's James Cook is the most likely player to score the first TD in Browns vs Bills.
Cook has a 14.9% chance of scoring the first TD at Huntington Bank Field, while the Bills RB has a 60.5% chance of scoring an anytime touchdown.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Browns First TD Tips
- Quinshon Judkins: 10.6% probability
- Harold Fannin: 5.4% probability
- Trayveon Williams: 4.6% probability
- Isaiah Bond: 3.0% probability
- Jerry Jeudy: 3.0% probability
Bills First TD Tips
- James Cook: 14.9% probability
- Josh Allen: 10.3% probability
- Khalil Shakir: 6.4% probability
- Ty Johnson: 5.1% probability
- Dalton Kincaid: 4.9% probability
Anytime Touchdown Scorer Tips
Browns Anytime TD Tips
- Quinshon Judkins: 49.7% probability
- Harold Fannin: 29.7% probability
- Trayveon Williams: 25.6% probability
- Isaiah Bond: 17.5% probability
- Jerry Jeudy: 17.4% probability
Bills Anytime TD Tips
- James Cook: 60.5% probability
- Josh Allen: 47.3% probability
- Khalil Shakir: 32.8% probability
- Ty Johnson: 27.4% probability
- Dalton Kincaid: 26.2% probability
Browns-Bills Projected Player Stats
Of the starting quarterbacks, the Browns' Shedeur Sanders is projected for 183 passing yards. The Bills' Josh Allen is expected to throw for 212 yards.
Browns Starting QB
- Shedeur Sanders: 183 projected passing yards
Bills Starting QB
- Josh Allen: 212 projected passing yards
Browns Rushing Yards
- Quinshon Judkins: 62 projected yards
- Trayveon Williams: 18 projected yards
- Shedeur Sanders: 15 projected yards
Bills Rushing Yards
- James Cook: 94 projected yards
- Josh Allen: 34 projected yards
- Ty Johnson: 14 projected yards
Browns Receiving Yards
- Harold Fannin: 53 projected yards
- Jerry Jeudy: 35 projected yards
- Isaiah Bond: 21 projected yards
- Cedric Tillman: 19 projected yards
- Quinshon Judkins: 16 projected yards
Bills Receiving Yards
- Khalil Shakir: 45 projected yards
- Dalton Kincaid: 38 projected yards
- Joshua Palmer: 29 projected yards
- Dawson Knox: 22 projected yards
- James Cook: 17 projected yards
Our model updates frequently, so refresh this article for the latest betting analysis before the Cleveland vs Buffalo game.
As always, see Stats Insider's Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
Browns vs Bills: Week 16 Essential Details
The NFL Week 16 match-up between the Browns and Bills at Huntington Bank Field is scheduled to begin at 5:00am AEDT on Monday.
- Teams: Cleveland Browns vs Buffalo Bills
- Date: Monday 22 December 2025
- Time: 5:00am AEDT
- Venue: Huntington Bank Field
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Cleveland vs Buffalo predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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