Browns vs 49ers Prediction and Preview - NFL Week 13, 2025
Last updated: Nov 25, 2025, 3:52PM | Published: Nov 23, 2025, 8:36AM
The Cleveland Browns will take on the favoured San Francisco 49ers in NFL Week 13 action at Huntington Bank Field on Monday, beginning at 5:00am AEDT.
This article features Stats Insider's best betting tips for the Browns vs 49ers game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the result of Monday's Cleveland vs San Francisco NFL game 10,000 times.
Our independent predictive analytics model gives the 49ers a 72% chance of winning against the Browns in Week 13 of the NFL season.
Browns vs 49ers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Huntington Bank Field are listed below:
- Head to Head: Browns $3.00, 49ers $1.41
- Line: Browns +5 ($1.91), 49ers -5 ($1.91)
- Total (Over/Under 38.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Browns at $3.00 and the 49ers at $1.41.
The Browns are 5-point underdogs against the 49ers, with odds of $1.91 available at Bet365.
For the favourite 49ers (-5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 38.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the 49ers (-5) are predicted to cover the line 52% of the time, while the 38.5-point over/under is expected to go over 53% of the time.
Browns vs 49ers: Best Bets
- Head to Head: San Francisco at $1.41 with Bet365
- Line: 49ers -5 at $1.91 with Bet365
- Total Points: Over 38.5 at $1.91 with Bet365
These Browns vs 49ers betting tips are based on detailed simulations and betting intelligence to give you the best possible advice every day of the year.
Browns vs 49ers: Prediction
Stats Insider's predicted final score for Browns vs 49ers at Huntington Bank Field in Week 13 is the 49ers winning 22-17.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the Cleveland vs San Francisco game in Week 13, including data-driven predictions and top betting tips.
18+. Odds correct at time of publishing and subject to change.Browns vs 49ers: TD Scorer Tips
Who will score an anytime touchdown in Browns vs 49ers? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in Browns vs 49ers.
McCaffrey has a 20.7% chance of getting in for six first at Huntington Bank Field, while the 49ers RB has a 68.0% chance of scoring an anytime touchdown.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Browns First TD Tips
- Quinshon Judkins: 10.1% probability
- David Njoku: 5.0% probability
- Cedric Tillman: 4.8% probability
- Harold Fannin: 4.2% probability
- Dylan Sampson: 3.9% probability
49ers First TD Tips
- Christian McCaffrey: 20.7% probability
- George Kittle: 10.2% probability
- Jauan Jennings: 7.1% probability
- Ricky Pearsall: 5.9% probability
- Brock Purdy: 3.2% probability
Anytime Touchdown Scorer Tips
Browns Anytime TD Tips
- Quinshon Judkins: 47.8% probability
- David Njoku: 27.5% probability
- Cedric Tillman: 26.6% probability
- Harold Fannin: 23.5% probability
- Dylan Sampson: 22.2% probability
49ers Anytime TD Tips
- Christian McCaffrey: 68.0% probability
- George Kittle: 42.8% probability
- Jauan Jennings: 32.3% probability
- Ricky Pearsall: 27.7% probability
- Brock Purdy: 16.0% probability
Browns-49ers Projected Player Stats
Of the starting quarterbacks, the Browns' Shedeur Sanders is projected to have a quiet game with 164 passing yards, while the 49ers' Brock Purdy is expected to throw for 217 yards.
Browns Starting QB
- Shedeur Sanders: 164 projected passing yards
49ers Starting QB
- Brock Purdy: 217 projected passing yards
Browns Rushing Yards
- Quinshon Judkins: 56 projected yards
- Dylan Sampson: 15 projected yards
- Shedeur Sanders: 10 projected yards
49ers Rushing Yards
- Christian McCaffrey: 70 projected yards
- Brian Robinson: 16 projected yards
- Brock Purdy: 15 projected yards
Browns Receiving Yards
- Jerry Jeudy: 34 projected yards
- Harold Fannin: 33 projected yards
- Cedric Tillman: 32 projected yards
- David Njoku: 30 projected yards
- Jamari Thrash: 10 projected yards
49ers Receiving Yards
- Jauan Jennings: 47 projected yards
- George Kittle: 46 projected yards
- Christian McCaffrey: 41 projected yards
- Ricky Pearsall: 41 projected yards
- Demarcus Robinson: 12 projected yards
Remember, our model updates regularly, so refresh this page for the latest betting predictions before the Cleveland vs San Francisco game.
As always, see our Best Bets for the best tips on every NFL game, plus predictions for a wide range of other sports.
Browns vs 49ers: Week 13 Essential Details
The NFL Week 13 game between the Browns and 49ers at Huntington Bank Field is scheduled to commence at 5:00am AEDT on Monday.
- Teams: Cleveland Browns vs San Francisco 49ers
- Date: Monday 1 December 2025
- Time: 5:00am AEDT
- Venue: Huntington Bank Field
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Cleveland vs San Francisco predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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