Bills vs Saints Prediction and Preview - NFL Week 4, 2025
Last updated: Sep 28, 2025, 5:03PM | Published: Sep 21, 2025, 4:01AM
The Buffalo Bills will take on the New Orleans Saints in NFL Week 4 action at Highmark Stadium on Monday, commencing at 3:00am AEST.
This article features Stats Insider's prediction and tips for the Bills vs Saints game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Using advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Buffalo vs New Orleans NFL game 10,000 times.
Our independent predictive analytics model currently gives the Bills an 89% chance of defeating the Saints at Highmark Stadium.
Bills vs Saints: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Highmark Stadium are listed below:
- Head to Head: Bills $1.08, Saints $9.00
- Line: Bills -14.5 ($1.91), Saints +14.5 ($1.91)
- Total (Over/Under 48.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Bills at $1.08 and the Saints at $9.00.
The Bills are 14.5-point favourites against the Saints, with odds of $1.91 available at Bet365.
For the underdog Saints (+14.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Saints (+14.5) are predicted to cover the line 53% of the time, while the 48.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Bills vs Saints: Best Bets
- Head to Head: New Orleans at $9.00 with Bet365
- Line: Saints +14.5 at $1.91 with Bet365
- Total Points: Under 48.5 at $1.91 with Bet365
These Bills vs Saints predictions are based on complex simulations and gambling expertise to bring you the best possible advice every time.
While the Bills have a higher chance of winning the game, betting on the Saints to win is our recommended option because of the edge found when comparing our data-led probabilities to the odds currently available.
Making use of the edges seen on Stats Insider is pivotal to being a profitable punter in the long run.
Bills vs Saints: Prediction
Stats Insider's predicted final score for Bills vs Saints at Highmark Stadium in Week 4 is the Bills winning 31-17.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Buffalo vs New Orleans game in Week 4, including data-driven predictions and live win probabilitiestips.
For in-depth analysis from US experts,, check out Dimers' detailed Bills vs Saints prediction.
18+. Odds correct at time of publishing and subject to change.Bills vs Saints: TD Scorer Tips
Who will score the first touchdown in Bills vs Saints? The data is in.
According to Stats Insider, Buffalo's James Cook is the most likely player to score the first touchdown in Bills vs Saints.
Cook has a 14.9% chance of scoring the first TD at Highmark Stadium, while the Bills RB has a 59.3% chance of reaching the end zone at any point in the game.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Bills First TD Tips
- James Cook: 14.9% probability
- Josh Allen: 11.7% probability
- Keon Coleman: 5.9% probability
- Dalton Kincaid: 5.0% probability
- Khalil Shakir: 4.9% probability
Saints First TD Tips
- Alvin Kamara: 9.6% probability
- Juwan Johnson: 5.4% probability
- Chris Olave: 5.1% probability
- Rashid Shaheed: 4.8% probability
- Spencer Rattler: 2.5% probability
Anytime Touchdown Scorer Tips
Bills Anytime TD Tips
- James Cook: 59.3% probability
- Josh Allen: 50.8% probability
- Keon Coleman: 29.9% probability
- Dalton Kincaid: 26.1% probability
- Khalil Shakir: 25.7% probability
Saints Anytime TD Tips
- Alvin Kamara: 39.3% probability
- Juwan Johnson: 24.3% probability
- Chris Olave: 23.3% probability
- Rashid Shaheed: 22.1% probability
- Spencer Rattler: 12.3% probability
Bills-Saints Projected Player Stats
Of the starting quarterbacks, the Bills' Josh Allen is projected for 230 passing yards. The Saints' Spencer Rattler is expected to throw for 217 yards.
Bills Starting QB
- Josh Allen: 230 projected passing yards
Saints Starting QB
- Spencer Rattler: 217 projected passing yards
Bills Rushing Yards
- James Cook: 78 projected yards
- Josh Allen: 27 projected yards
- Ray Davis: 22 projected yards
Saints Rushing Yards
- Alvin Kamara: 56 projected yards
- Spencer Rattler: 22 projected yards
- Kendre Miller: 20 projected yards
Bills Receiving Yards
- Keon Coleman: 46 projected yards
- Khalil Shakir: 46 projected yards
- Dalton Kincaid: 40 projected yards
- Joshua Palmer: 31 projected yards
- James Cook: 17 projected yards
Saints Receiving Yards
- Chris Olave: 65 projected yards
- Juwan Johnson: 47 projected yards
- Rashid Shaheed: 43 projected yards
- Alvin Kamara: 23 projected yards
- Brandin Cooks: 23 projected yards
Remember, our model updates frequently, so refresh this page for the latest betting tips before the Buffalo vs New Orleans game.
As always, see our Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.
Bills vs Saints: Week 4 Essential Details
The NFL Week 4 game between the Bills and Saints at Highmark Stadium is scheduled to start at 3:00am AEST on Monday.
- Teams: Buffalo Bills vs New Orleans Saints
- Date: Monday 29 September 2025
- Time: 3:00am AEST
- Venue: Highmark Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Buffalo vs New Orleans predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's important that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on NFL
Stats Insider is your go-to source for betting on the NFL in Australia, with the latest NFL betting news, predictions for every NFL game, and Super Bowl probabilities for the NFL.
