Bills vs Lions Prediction and Preview - NFL Week 2, 2026
Last updated: Sep 18, 2026, 12:05AM | Published: Sep 11, 2026, 4:06AM
The Buffalo Bills will face the Detroit Lions in NFL Week 2 action at Highmark Stadium on Friday, starting at 10:15am AEST.
This article features Stats Insider's prediction and tips for the Bills vs Lions game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the result of Friday's Buffalo vs Detroit NFL match-up 10,000 times.
Our leading predictive analytics model currently gives the Bills a 69% chance of beating the Lions at Highmark Stadium.
Bills vs Lions: Odds
The current Bet365 betting odds in Australia for Friday's NFL game at Highmark Stadium are listed here:
- Head to Head: Bills $1.40, Lions $3.05
- Line: Bills -5.5 ($1.91), Lions +5.5 ($1.91)
- Total (Over/Under 54.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Bills at $1.40 and the Lions at $3.05.
The Bills are listed as 5.5-point favourites against the Lions, with odds of $1.91 available at Bet365.
For the underdog Lions (+5.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 54.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Bills and the Lions have a 50% chance of covering the line.
The 54.5-point over/under is expected to stay under 54% of the time.
Bills vs Lions: Betting Tips
- Head to Head: Detroit at $3.05 with Bet365
- Line: Lions +5.5 at $1.91 with Bet365
- Total Points: Under 54.5 at $1.91 with Bet365
Stats Insider's Bills vs Lions betting tips are based on world-class modelling and betting experience to help you place smarter bets with your chosen online bookie.
While the Bills have a higher chance of winning the game, betting on the Lions to win is our preferred option because of the edge identified when comparing our data-led probabilities to the odds currently on offer.
Taking advantage of the edges published on Stats Insider is pivotal to being profitable in the long run.
Bills vs Lions: Prediction
Stats Insider's predicted final score for Bills vs Lions at Highmark Stadium in Week 2 is the Bills winning 29-23.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the Buffalo vs Detroit game in Week 2, including data-driven predictions and live win probabilitiestips.
18+. Odds correct at time of publishing and subject to change.Bills vs Lions: TD Scorer Tips
Who will score an anytime touchdown in Bills vs Lions? The data is in.
According to Stats Insider, Detroit's Jahmyr Gibbs is the most likely player to score the first touchdown in Bills vs Lions.
Gibbs has a 17.6% chance of getting in for six first at Highmark Stadium, while the Lions RB has a 70.7% chance of registering an anytime touchdown.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Bills First TD Tips
- James Cook: 12.9% probability
- Josh Allen: 10.3% probability
- DJ Moore: 6.8% probability
- Dalton Kincaid: 5.8% probability
- Khalil Shakir: 4.5% probability
Lions First TD Tips
- Jahmyr Gibbs: 17.6% probability
- Amon-Ra St. Brown: 8.0% probability
- Jameson Williams: 5.3% probability
- Sam LaPorta: 4.7% probability
- Isaac TeSlaa: 2.2% probability
Anytime Touchdown Scorer Tips
Bills Anytime TD Tips
- James Cook: 57.3% probability
- Josh Allen: 49.2% probability
- DJ Moore: 36.0% probability
- Dalton Kincaid: 31.6% probability
- Khalil Shakir: 25.7% probability
Lions Anytime TD Tips
- Jahmyr Gibbs: 70.7% probability
- Amon-Ra St. Brown: 42.9% probability
- Jameson Williams: 30.8% probability
- Sam LaPorta: 28.2% probability
- Isaac TeSlaa: 14.3% probability
Bills-Lions Projected Player Stats
Of the starting quarterbacks, the Bills' Josh Allen is projected for 251 passing yards, while the Lions' Jared Goff is expected to throw for 261 yards.
Bills Starting QB
- Josh Allen: 251 projected passing yards
Lions Starting QB
- Jared Goff: 261 projected passing yards
Bills Rushing Yards
- James Cook: 88 projected yards
- Josh Allen: 35 projected yards
- Ray Davis: 16 projected yards
Lions Rushing Yards
- Jahmyr Gibbs: 92 projected yards
- Sione Vaki: 11 projected yards
- Jared Goff: 3 projected yards
Bills Receiving Yards
- DJ Moore: 67 projected yards
- Dalton Kincaid: 55 projected yards
- Khalil Shakir: 49 projected yards
- James Cook: 22 projected yards
- Keon Coleman: 21 projected yards
Lions Receiving Yards
- Amon-Ra St. Brown: 85 projected yards
- Jameson Williams: 62 projected yards
- Sam LaPorta: 48 projected yards
- Jahmyr Gibbs: 34 projected yards
- Isaac TeSlaa: 24 projected yards
Our model updates regularly, so bookmark this article for the latest betting tips before the Buffalo vs Detroit match-up.
As always, see Stats Insider's Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.
Bills vs Lions: Week 2 Essential Details
The NFL Week 2 match-up between the Bills and Lions at Highmark Stadium is scheduled to commence at 10:15am AEST on Friday.
- Teams: Buffalo Bills vs Detroit Lions
- Date: Friday 18 September 2026
- Time: 10:15am AEST
- Venue: Highmark Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Buffalo vs Detroit predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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