Bills vs Lions Prediction and Preview - NFL Week 2, 2026
Last updated: Sep 11, 2026, 8:01PM | Published: Sep 11, 2026, 4:06AM
The Buffalo Bills will sqaure off with the Detroit Lions in NFL Week 2 action at Highmark Stadium on Friday, September 18, beginning at 10:15am AEST.
This article features Stats Insider's best betting tips for the Bills vs Lions game, along with the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the outcome of Lions vs Bills 10,000 times.
Our independent predictive analytics model gives the Bills a 62% chance of winning against the Lions at Highmark Stadium.
Bills vs Lions: Odds
The latest Bet365 betting odds in Australia for this NFL game at Highmark Stadium are listed below:
- Head to Head: Bills $1.62, Lions $2.35
- Line: Bills -3.5 ($1.91), Lions +3.5 ($1.91)
- Total (Over/Under 51.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Bills at $1.62 and the Lions at $2.35.
The Bills are 3.5-point favourites against the Lions, with odds of $1.91 available at Bet365.
For the underdog Lions (+3.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 51.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Lions (+3.5) are predicted to cover the line 57% of the time, while the 51.5-point over/under is expected to stay under 52% of the time.
Bills vs Lions: Best Bets
- Head to Head: Buffalo at $1.62 with Bet365
- Line: Lions +3.5 at $1.91 with Bet365
- Total Points: Under 51.5 at $1.91 with Bet365
If you see a 🔥, you know you've found one of Stats Insider's best bets of the day across any sport.
Today's Bills vs Lions best bets are based on world-class simulations and betting intelligence to help you place more informed bets with your chosen online bookie.
Bills vs Lions: Prediction
Stats Insider's predicted final score for Bills vs Lions at Highmark Stadium in Week 2 is the Bills winning 27-23.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Buffalo vs Detroit game in Week 2, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.Our model updates frequently, so keep checking this article for the latest betting tips before the Buffalo vs Detroit game.
As always, see our Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.
Bills vs Lions: Week 2 Essential Details
The NFL Week 2 game between the Bills and Lions at Highmark Stadium is scheduled to begin at 10:15am AEST on Friday, September 18.
- Teams: Buffalo Bills vs Detroit Lions
- Date: Friday 18 September 2026
- Time: 10:15am AEST
- Venue: Highmark Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Buffalo vs Detroit predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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