Bills vs Eagles Prediction and Preview - NFL Week 17, 2025
Last updated: Dec 28, 2025, 9:25PM | Published: Dec 22, 2025, 12:15AM
The Buffalo Bills will take on the Philadelphia Eagles in NFL Week 17 action at Highmark Stadium on Monday, beginning at 8:25am AEDT.
This article features Stats Insider's prediction and tips for the Bills vs Eagles game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Monday's Buffalo vs Philadelphia NFL game 10,000 times.
Our independent predictive analytics model gives the Bills a 60% chance of beating the Eagles in Week 17 of the NFL season.
Bills vs Eagles: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Highmark Stadium are shown below:
- Head to Head: Bills $1.56, Eagles $2.50
- Line: Bills -3 ($1.91), Eagles +3 ($1.91)
- Total (Over/Under 45 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Bills at $1.56 and the Eagles at $2.50.
The Bills are listed as 3-point favourites against the Eagles, with odds of $1.91 available at Bet365.
For the underdog Eagles (+3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 45 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookies have got it right and both the Bills and the Eagles have a 50% chance of covering the line.
The 45-point over/under is expected to stay under 51% of the time.
Bills vs Eagles: Best Bets
- Head to Head: Philadelphia at $2.50 with Bet365
- Line: Eagles +3 at $1.91 with Bet365
- Total Points: Under 45 at $1.91 with Bet365
Our Bills vs Eagles best bets are based on market-leading simulations and betting experience to bring you the best possible advice around the clock.
While the Bills have a higher chance of winning the game, betting on the Eagles to win is our preferred option because of the edge identified when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges seen here at Stats Insider is crucial to achieving long-term success as a sports bettor.
Bills vs Eagles: Prediction
Stats Insider's predicted final score for Bills vs Eagles at Highmark Stadium in Week 17 is the Bills winning 23-20.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Buffalo vs Philadelphia game in Week 17, including data-driven predictions and live win probabilitiestips.
Get expert analysis from the US with Dimers' in-depth Bills vs Eagles prediction.
18+. Odds correct at time of publishing and subject to change.Bills vs Eagles: TD Scorer Tips
Who will score the first touchdown in Bills vs Eagles? The latest data is in.
According to Stats Insider, Buffalo's James Cook is the most likely player to score the first TD in Bills vs Eagles.
Cook has a 13.0% chance of getting in for six first at Highmark Stadium, while the Bills RB has a 53.8% chance of scoring an anytime touchdown.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Bills First TD Tips
- James Cook: 13.0% probability
- Josh Allen: 9.9% probability
- Khalil Shakir: 5.1% probability
- Dawson Knox: 4.3% probability
- Ty Johnson: 3.1% probability
Eagles First TD Tips
- Saquon Barkley: 10.2% probability
- Jalen Hurts: 8.9% probability
- A.J. Brown: 6.6% probability
- DeVonta Smith: 5.5% probability
- Dallas Goedert: 5.2% probability
Anytime Touchdown Scorer Tips
Bills Anytime TD Tips
- James Cook: 53.8% probability
- Josh Allen: 44.5% probability
- Khalil Shakir: 26.3% probability
- Dawson Knox: 22.5% probability
- Ty Johnson: 16.6% probability
Eagles Anytime TD Tips
- Saquon Barkley: 46.7% probability
- Jalen Hurts: 42.1% probability
- A.J. Brown: 33.2% probability
- DeVonta Smith: 28.9% probability
- Dallas Goedert: 27.5% probability
Bills-Eagles Projected Player Stats
Of the starting quarterbacks, the Bills' Josh Allen is projected for 201 passing yards, while the Eagles' Jalen Hurts is expected to throw for 190 yards.
Bills Starting QB
- Josh Allen: 201 projected passing yards
Eagles Starting QB
- Jalen Hurts: 190 projected passing yards
Bills Rushing Yards
- James Cook: 93 projected yards
- Josh Allen: 36 projected yards
- Ty Johnson: 12 projected yards
Eagles Rushing Yards
- Saquon Barkley: 82 projected yards
- Jalen Hurts: 36 projected yards
- Tank Bigsby: 13 projected yards
Bills Receiving Yards
- Khalil Shakir: 45 projected yards
- Dawson Knox: 28 projected yards
- Joshua Palmer: 24 projected yards
- James Cook: 17 projected yards
- Ty Johnson: 15 projected yards
Eagles Receiving Yards
- A.J. Brown: 64 projected yards
- DeVonta Smith: 52 projected yards
- Dallas Goedert: 36 projected yards
- Saquon Barkley: 16 projected yards
- Jahan Dotson: 14 projected yards
Our model updates regularly, so keep checking this page for the latest betting tips before the Buffalo vs Philadelphia match-up.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.
Bills vs Eagles: Week 17 Essential Details
The NFL Week 17 game between the Bills and Eagles at Highmark Stadium is scheduled to commence at 8:25am AEDT on Monday.
- Teams: Buffalo Bills vs Philadelphia Eagles
- Date: Monday 29 December 2025
- Time: 8:25am AEDT
- Venue: Highmark Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Buffalo vs Philadelphia predictions are based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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