Bills vs Chargers Prediction and Preview - NFL Week 3, 2026
Last updated: Sep 27, 2026, 5:02PM | Published: Sep 20, 2026, 4:02AM
The Buffalo Bills will take on the Los Angeles Chargers in NFL Week 3 action at Highmark Stadium on Monday, beginning at 3:00am AEST.
This article features Stats Insider's prediction and tips for the Bills vs Chargers game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Using advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Buffalo vs LA Chargers NFL game 10,000 times.
Our independent predictive analytics model currently gives the Bills a 76% chance of defeating the Chargers at Highmark Stadium.
Bills vs Chargers: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Highmark Stadium are shown below:
- Head to Head: Bills $1.28, Chargers $3.75
- Line: Bills -7.5 ($1.91), Chargers +7.5 ($1.91)
- Total (Over/Under 50.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Bills at $1.28 and the Chargers at $3.75.
The Bills are listed as 7.5-point favourites against the Chargers, with odds of $1.91 available at Bet365.
For the underdog Chargers (+7.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 50.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Bills and the Chargers have a 50% chance of covering the line.
The 50.5-point over/under is expected to stay under 52% of the time.
Bills vs Chargers: Betting Tips
- Head to Head: Buffalo at $1.28 with Bet365
- Line: Chargers +7.5 at $1.91 with Bet365
- Total Points: Under 50.5 at $1.91 with Bet365
Stats Insider's Bills vs Chargers best bets are based on detailed simulations and betting expertise to provide you with the best possible advice 24/7/365.
Bills vs Chargers: Prediction
Stats Insider's predicted final score for Bills vs Chargers at Highmark Stadium in Week 3 is the Bills prevailing 28-20.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the Buffalo vs LA Chargers game in Week 3, including data-driven predictions and computer tips.
18+. Odds correct at time of publishing and subject to change.Bills vs Chargers: TD Scorer Tips
Who will score the first touchdown in Bills vs Chargers? The data is in.
According to Stats Insider, Buffalo's James Cook is the most likely player to score the first touchdown in Bills vs Chargers.
Cook has a 14.1% chance of scoring the first TD at Highmark Stadium, while the Bills RB has a 57.6% chance of reaching the end zone at any point during the game.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Bills First TD Tips
- James Cook: 14.1% probability
- Josh Allen: 12.7% probability
- DJ Moore: 8.2% probability
- Dalton Kincaid: 5.4% probability
- Dawson Knox: 3.0% probability
Chargers First TD Tips
- Omarion Hampton: 11.3% probability
- Ladd McConkey: 6.8% probability
- Quentin Johnston: 4.9% probability
- Oronde Gadsden: 4.1% probability
- Keaton Mitchell: 4.1% probability
Anytime Touchdown Scorer Tips
Bills Anytime TD Tips
- James Cook: 57.6% probability
- Josh Allen: 54.1% probability
- DJ Moore: 39.2% probability
- Dalton Kincaid: 28.1% probability
- Dawson Knox: 16.6% probability
Chargers Anytime TD Tips
- Omarion Hampton: 48.7% probability
- Ladd McConkey: 33.1% probability
- Quentin Johnston: 25.1% probability
- Oronde Gadsden: 21.6% probability
- Keaton Mitchell: 21.5% probability
Bills-Chargers Projected Player Stats
Of the starting quarterbacks, the Bills' Josh Allen is projected for 245 passing yards, while the Chargers' Justin Herbert is expected to throw for 232 yards.
Bills Starting QB
- Josh Allen: 245 projected passing yards
Chargers Starting QB
- Justin Herbert: 232 projected passing yards
Bills Rushing Yards
- James Cook: 86 projected yards
- Josh Allen: 37 projected yards
- Ray Davis: 15 projected yards
Chargers Rushing Yards
- Omarion Hampton: 62 projected yards
- Justin Herbert: 24 projected yards
- Keaton Mitchell: 22 projected yards
Bills Receiving Yards
- Dalton Kincaid: 59 projected yards
- DJ Moore: 54 projected yards
- Khalil Shakir: 48 projected yards
- Keon Coleman: 22 projected yards
- James Cook: 16 projected yards
Chargers Receiving Yards
- Ladd McConkey: 64 projected yards
- Quentin Johnston: 42 projected yards
- Oronde Gadsden: 40 projected yards
- Tre' Harris: 37 projected yards
- Omarion Hampton: 15 projected yards
Remember, our model updates frequently, so keep checking this page for the latest betting tips before the Buffalo vs LA Chargers match-up.
As always, see our Best Bets to get the best tips on every NFL game, plus predictions for a wide range of other sports.
Bills vs Chargers: Week 3 Essential Details
The NFL Week 3 game between the Bills and Chargers at Highmark Stadium is scheduled to start at 3:00am AEST on Monday.
- Teams: Buffalo Bills vs Los Angeles Chargers
- Date: Monday 28 September 2026
- Time: 3:00am AEST
- Venue: Highmark Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Buffalo vs LA Chargers predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's important to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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