Astros vs Mariners Prediction and MLB Tips - 22 September 2025
Last updated: Sep 21, 2025, 11:10PM | Published: Sep 20, 2025, 9:29PM
The Houston Astros will take on the Seattle Mariners in Game of the League Series at Daikin Park on Monday, starting at 9:10am AEST.
Jason Alexander (4-1, 4.04 ERA) will be on the bump for the Astros, while the Mariners will counter with Logan Gilbert (5-6, 3.52 ERA).
This article features Stats Insider's prediction and tips for the Astros vs Mariners game, along with the latest betting odds in Australia.
Who Will Win?
Using trusted computer power and data, Stats Insider has simulated the outcome of Monday's Houston vs Seattle MLB match-up 10,000 times.
Our proven predictive analytics model gives the Mariners a 55% chance of beating the Astros at Daikin Park.
Astros vs Mariners: Odds
The current betting odds in Australia for Monday's MLB game at Daikin Park are listed here:
- Head to Head: Astros $2.25, Mariners $1.67
- Line: Astros +1.5 ($1.72), Mariners -1.5 ($2.20)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Astros at $2.25 and the Mariners at $1.67.
The Astros are listed as 1.5-run underdogs against the Mariners, with odds of $1.72 available at TAB.
For the favourite Mariners (-1.5) to cover the line, TAB offers odds of $2.20.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Astros (+1.5) are predicted to cover the line 58% of the time, while the 8.5-run over/under is expected to go over 53% of the time.
Astros vs Mariners: Betting Tips
- Head to Head: Houston at $2.25 with TAB
- Line: Astros +1.5 at $1.72 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
Today's Astros vs Mariners betting tips are based on complex simulations and gambling intelligence to bring you the best possible advice every day of the year.
While the Mariners have a higher chance of winning the game, betting on the Astros to win is our preferred option because of the 2.0% edge found when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges seen on Stats Insider is pivotal to achieving long-term success as a sports bettor.
Astros vs Mariners: Prediction
Stats Insider provides full coverage of the Houston vs Seattle game on Monday, including data-driven predictions and top betting tips.
Remember, our model updates frequently, so refresh this page for the latest betting analysis before the Houston vs Seattle match-up.
As always, see our Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
Astros vs Mariners: Essential Details
The match-up between the Astros and Mariners at Daikin Park is scheduled to start at 9:10am AEST on Monday.
- Teams: Houston Astros vs Seattle Mariners
- Date: Monday 22 September 2025
- Time: 9:10am AEST
- Venue: Daikin Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Houston vs Seattle predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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