Astros vs Cardinals Prediction and MLB Tips - 20 April 2026
Last updated: Apr 19, 2026, 6:10PM | Published: Apr 18, 2026, 6:29PM
The Houston Astros will sqaure off with the St. Louis Cardinals in MLB action at Daikin Park on Monday, beginning at 4:10am AEST.
The Astros will send Mike Burrows (1-3, 6.54 ERA) to the mound, pitting him against Matthew Liberatore (0-1, 4.29 ERA) for the Cardinals.
This article features Stats Insider's prediction and tips for the Astros vs Cardinals game, plus the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the outcome of Monday's Houston vs St. Louis MLB match-up 10,000 times.
Our independent predictive analytics model gives the Astros a 58% chance of beating the Cardinals at Daikin Park.
Astros vs Cardinals: Odds
The latest betting odds in Australia for Monday's MLB game at Daikin Park are listed here:
- Head to Head: Astros $1.71, Cardinals $2.20
- Line: Astros -1.5 ($2.45), Cardinals +1.5 ($1.59)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Astros at $1.71 and the Cardinals at $2.20.
The Astros are 1.5-run favourites against the Cardinals, with odds of $2.45 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.59.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 59% of the time, while the 8.5-run over/under is expected to go over 53% of the time.
Astros vs Cardinals: Betting Tips
- Head to Head: Houston at $1.71 with TAB
- Line: Astros -1.5 at $2.45 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
These Astros vs Cardinals predictions are based on complex simulations and gambling experience to bring you the best possible advice every time.
Although the Cardinals are more likely to cover the line, our best bet of Astros -1.5 is based on the likelihood of that happening, as projected by our predictive analytics model, and the top odds available.
Astros vs Cardinals: Prediction
Stats Insider provides full coverage of the Houston vs St. Louis game on Monday, including data-driven predictions and live win probabilitiestips.
Our model updates frequently, so bookmark this article for the latest betting analysis before the Houston vs St. Louis game.
As always, see Stats Insider's Best Bets to get betting tips on every MLB game, as well as predictions for a wide range of other sports.
Astros vs Cardinals: Essential Details
The match-up between the Astros and Cardinals at Daikin Park is scheduled to start at 4:10am AEST on Monday.
- Teams: Houston Astros vs St. Louis Cardinals
- Date: Monday 20 April 2026
- Time: 4:10am AEST
- Venue: Daikin Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Houston vs St. Louis predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's vital that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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