49ers vs Titans Prediction and Preview - NFL Week 15, 2025
Last updated: Dec 14, 2025, 9:25PM | Published: Dec 7, 2025, 5:00AM
The San Francisco 49ers will face the Tennessee Titans in NFL Week 15 action at Levi's Stadium on Monday, starting at 8:25am AEDT.
This article features Stats Insider's top betting tips for the 49ers vs Titans game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the result of Monday's San Francisco vs Tennessee NFL game 10,000 times.
Our proven predictive analytics model gives the 49ers an 87% chance of winning against the Titans at Levi's Stadium.
49ers vs Titans: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are listed below:
- Head to Head: 49ers $1.12, Titans $6.75
- Line: 49ers -12.5 ($1.91), Titans +12.5 ($1.91)
- Total (Over/Under 45 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.12 and the Titans at $6.75.
The 49ers are listed as 12.5-point favourites against the Titans, with odds of $1.91 available at Bet365.
For the underdog Titans (+12.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 45 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Titans (+12.5) are predicted to cover the line 52% of the time, while the 45-point over/under is expected to stay under 51% of the time.
49ers vs Titans: Betting Tips
- Head to Head: Tennessee at $6.75 with Bet365
- Line: Titans +12.5 at $1.91 with Bet365
- Total Points: Under 45 at $1.91 with Bet365
Stats Insider's 49ers vs Titans predictions are based on market-leading simulations and wagering expertise to help you place more informed bets with your chosen online bookie.
While the 49ers have a higher chance of winning the game, betting on the Titans to win is our preferred option due to the edge found when comparing our data-driven probabilities to the odds currently on offer.
Making use of the edges published on Stats Insider is one of the keys to achieving long-term success as a sports bettor.
49ers vs Titans: Prediction
Stats Insider's predicted final score for 49ers vs Titans at Levi's Stadium in Week 15 is the 49ers winning 27-16.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the San Francisco vs Tennessee game in Week 15, including data-driven predictions and free betting tips.
For in-depth analysis from US experts,, check out Dimers' detailed 49ers vs Titans prediction.
18+. Odds correct at time of publishing and subject to change.49ers vs Titans: TD Scorer Tips
Who will score the first touchdown in 49ers vs Titans? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in 49ers vs Titans.
McCaffrey has a 20.6% chance of scoring the first TD at Levi's Stadium, while the 49ers RB has a 66.6% chance of reaching the end zone at any point in the game.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 20.6% probability
- George Kittle: 9.5% probability
- Jauan Jennings: 7.6% probability
- Ricky Pearsall: 5.4% probability
- Brian Robinson: 4.7% probability
Titans First TD Tips
- Tyjae Spears: 5.7% probability
- Tony Pollard: 5.6% probability
- Chimere Dike: 5.5% probability
- Elic Ayomanor: 5.1% probability
- Gunnar Helm: 3.4% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 66.6% probability
- George Kittle: 39.8% probability
- Jauan Jennings: 33.2% probability
- Ricky Pearsall: 24.9% probability
- Brian Robinson: 22.1% probability
Titans Anytime TD Tips
- Tyjae Spears: 23.3% probability
- Tony Pollard: 23.0% probability
- Chimere Dike: 22.6% probability
- Elic Ayomanor: 21.4% probability
- Gunnar Helm: 14.5% probability
49ers-Titans Projected Player Stats
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 245 passing yards. The Titans' Cam Ward is expected to throw for 205 yards.
49ers Starting QB
- Brock Purdy: 245 projected passing yards
Titans Starting QB
- Cam Ward: 205 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 69 projected yards
- Brian Robinson: 32 projected yards
- Brock Purdy: 12 projected yards
Titans Rushing Yards
- Tony Pollard: 51 projected yards
- Tyjae Spears: 22 projected yards
- Cam Ward: 13 projected yards
49ers Receiving Yards
- George Kittle: 61 projected yards
- Jauan Jennings: 54 projected yards
- Ricky Pearsall: 45 projected yards
- Christian McCaffrey: 44 projected yards
- Demarcus Robinson: 18 projected yards
Titans Receiving Yards
- Chimere Dike: 38 projected yards
- Elic Ayomanor: 37 projected yards
- Gunnar Helm: 28 projected yards
- Chig Okonkwo: 28 projected yards
- Van Jefferson: 27 projected yards
Our model updates regularly, so bookmark this article for the latest betting tips before the San Francisco vs Tennessee game.
As always, see Stats Insider's Best Bets for the best tips for every NFL game, as well as predictions for a wide range of other sports.
49ers vs Titans: Week 15 Essential Details
The NFL Week 15 match-up between the 49ers and Titans at Levi's Stadium is scheduled to begin at 8:25am AEDT on Monday.
- Teams: San Francisco 49ers vs Tennessee Titans
- Date: Monday 15 December 2025
- Time: 8:25am AEDT
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our San Francisco vs Tennessee predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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