49ers vs Titans Prediction and Preview - NFL Week 15, 2025

The San Francisco 49ers will face the Tennessee Titans in NFL Week 15 action at Levi's Stadium on Monday, December 15, starting at 8:25am AEDT.

This article features Stats Insider's free betting tips for the 49ers vs Titans game, plus the latest betting odds in Australia.

Who Will Win?

Based on advanced computer power and data, Stats Insider has simulated the result of Titans vs 49ers 10,000 times.

Our proven predictive analytics model gives the 49ers an 86% chance of defeating the Titans at Levi's Stadium.

49ers vs Titans: Odds

The latest Bet365 betting odds in Australia for this NFL game at Levi's Stadium are listed here:

• Head to Head: 49ers $1.10, Titans $7.25
• Line: 49ers -12.5 ($1.91), Titans +12.5 ($1.91)
• Total (Over/Under 42.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.10 and the Titans at $7.25.

The 49ers are listed as 12.5-point favourites against the Titans, with odds of $1.91 available at Bet365.

For the underdog Titans (+12.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 42.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the Titans (+12.5) are predicted to cover the line 52% of the time, while the 42.5-point over/under is expected to go over 58% of the time.

49ers vs Titans: Best Bets

• Head to Head: Tennessee at $7.25 with Bet365
• Line: Titans +12.5 at $1.91 with Bet365
• Total Points: Over 42.5 at $1.91 with Bet365

If you see a 🔥, you know it's one of Stats Insider's best bets of the day across any sport.

Our 49ers vs Titans betting tips are based on market-leading simulations and gambling experience to help you place smarter bets with your chosen online bookie.

While the 49ers have a higher chance of winning the game, betting on the Titans to win is our preferred option because of the edge identified when comparing our data-driven probabilities to the odds currently available.

Making use of the edges published here at Stats Insider is pivotal to achieving long-term profitability.

49ers vs Titans: Prediction

Stats Insider's predicted final score for 49ers vs Titans at Levi's Stadium in Week 15 is the 49ers winning 27-16.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full coverage of the San Francisco vs Tennessee game in Week 15, including data-driven predictions and expert tips.

Our model updates regularly, so keep checking this article for the latest betting tips before the San Francisco vs Tennessee match-up.

As always, see Stats Insider's Best Bets for the best tips for every NFL game, as well as predictions for a wide range of other sports.

49ers vs Titans: Week 15 Essential Details

The NFL Week 15 game between the 49ers and Titans at Levi's Stadium is scheduled to begin at 8:25am AEDT on Monday, December 15.

• Teams: San Francisco 49ers vs Tennessee Titans
• Date: Monday 15 December 2025
• Time: 8:25am AEDT
• Venue: Levi's Stadium

All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.

Conclusion

Our San Francisco vs Tennessee predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you choose to use our predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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