49ers vs Seahawks Prediction and Preview - NFL Week 18, 2026
Last updated: Jan 4, 2026, 1:06AM | Published: Dec 30, 2025, 1:50AM
The San Francisco 49ers will sqaure off with the Seattle Seahawks in NFL Week 18 action at Levi's Stadium on Sunday, starting at 12:00pm AEDT.
This article features Stats Insider's free betting tips for the 49ers vs Seahawks game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Sunday's San Francisco vs Seattle NFL match-up 10,000 times.
Our proven predictive analytics model currently gives the Seahawks a 56% chance of beating the 49ers at Levi's Stadium.
49ers vs Seahawks: Odds
The latest Bet365 betting odds in Australia for Sunday's NFL game at Levi's Stadium are shown here:
- Head to Head: 49ers $2.30, Seahawks $1.64
- Line: 49ers +2.5 ($1.91), Seahawks -2.5 ($1.91)
- Total (Over/Under 48.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $2.30 and the Seahawks at $1.64.
The 49ers are 2.5-point underdogs against the Seahawks, with odds of $1.91 available at Bet365.
For the favourite Seahawks (-2.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the 49ers (+2.5) are predicted to cover the line 58% of the time, while the 48.5-point over/under is expected to stay under 53% of the time.
49ers vs Seahawks: Best Bets
- Head to Head: San Francisco at $2.30 with Bet365
- Line: 49ers +2.5 at $1.91 with Bet365
- Total Points: Under 48.5 at $1.91 with Bet365
When you see a 🔥, that means you've found one of Stats Insider's best bets for today across all sports.
These 49ers vs Seahawks predictions are based on detailed modelling and gambling expertise to help you place more informed bets with your chosen online bookie.
While the Seahawks have a higher chance of winning the game, betting on the 49ers to win is our recommended option due to the edge identified when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges seen here at Stats Insider is pivotal to being profitable in the long run.
49ers vs Seahawks: Prediction
Stats Insider's predicted final score for 49ers vs Seahawks at Levi's Stadium in Week 18 is the Seahawks winning 24-23.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the San Francisco vs Seattle game in Week 18, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.49ers vs Seahawks: TD Scorer Tips
Who will score an anytime touchdown in 49ers vs Seahawks? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in 49ers vs Seahawks.
McCaffrey has a 15.8% chance of getting in for six first at Levi's Stadium, while the 49ers RB has a 59.8% chance of registering an anytime touchdown.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 15.8% probability
- George Kittle: 7.8% probability
- Jauan Jennings: 6.9% probability
- Brock Purdy: 3.0% probability
- Demarcus Robinson: 2.6% probability
Seahawks First TD Tips
- Jaxon Smith-Njigba: 10.7% probability
- Zach Charbonnet: 9.7% probability
- AJ Barner: 7.4% probability
- Kenneth Walker: 7.3% probability
- Cooper Kupp: 4.4% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 59.8% probability
- George Kittle: 36.0% probability
- Jauan Jennings: 32.6% probability
- Brock Purdy: 15.9% probability
- Demarcus Robinson: 13.7% probability
Seahawks Anytime TD Tips
- Jaxon Smith-Njigba: 46.6% probability
- Zach Charbonnet: 43.4% probability
- AJ Barner: 35.1% probability
- Kenneth Walker: 34.8% probability
- Cooper Kupp: 22.9% probability
49ers-Seahawks Projected Player Stats
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 246 passing yards, while the Seahawks' Sam Darnold is expected to throw for 238 yards.
49ers Starting QB
- Brock Purdy: 246 projected passing yards
Seahawks Starting QB
- Sam Darnold: 238 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 70 projected yards
- Brock Purdy: 19 projected yards
- Brian Robinson: 18 projected yards
Seahawks Rushing Yards
- Kenneth Walker: 54 projected yards
- Zach Charbonnet: 45 projected yards
- Sam Darnold: 8 projected yards
49ers Receiving Yards
- George Kittle: 62 projected yards
- Jauan Jennings: 49 projected yards
- Christian McCaffrey: 46 projected yards
- Kendrick Bourne: 32 projected yards
- Demarcus Robinson: 23 projected yards
Seahawks Receiving Yards
- Jaxon Smith-Njigba: 101 projected yards
- AJ Barner: 41 projected yards
- Cooper Kupp: 39 projected yards
- Rashid Shaheed: 35 projected yards
- Kenneth Walker: 16 projected yards
Remember, our model updates frequently, so refresh this page for the latest betting analysis before the San Francisco vs Seattle game.
As always, see our Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.
49ers vs Seahawks: Week 18 Essential Details
The NFL Week 18 match-up between the 49ers and Seahawks at Levi's Stadium is scheduled to begin at 12:00pm AEDT on Sunday.
- Teams: San Francisco 49ers vs Seattle Seahawks
- Date: Sunday 4 January 2026
- Time: 12:00pm AEDT
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our San Francisco vs Seattle predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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