49ers vs Seahawks Prediction and Preview - NFL Week 18, 2026
Last updated: Dec 30, 2025, 7:01AM | Published: Dec 30, 2025, 1:50AM
The San Francisco 49ers will sqaure off with the Seattle Seahawks in NFL Week 18 action at Levi's Stadium on Sunday, starting at 12:00pm AEDT.
This article features Stats Insider's top betting tips for the 49ers vs Seahawks game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the result of Sunday's San Francisco vs Seattle NFL game 10,000 times.
Our independent predictive analytics model currently gives the Seahawks a 54% chance of beating the 49ers in Week 18 of the NFL season.
49ers vs Seahawks: Odds
The current Bet365 betting odds in Australia for Sunday's NFL game at Levi's Stadium are listed below:
- Head to Head: 49ers $2.00, Seahawks $1.83
- Line: 49ers +1.5 ($1.91), Seahawks -1.5 ($1.91)
- Total (Over/Under 49.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $2.00 and the Seahawks at $1.83.
The 49ers are listed as 1.5-point underdogs against the Seahawks, with odds of $1.91 available at Bet365.
For the favourite Seahawks (-1.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 49.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the 49ers and the Seahawks have a 50% chance of covering the line.
The 49.5-point over/under is expected to stay under 53% of the time.
49ers vs Seahawks: Betting Tips
- Head to Head: Seattle at $1.83 with Bet365
- Line: Seahawks -1.5 at $1.91 with Bet365
- Total Points: Under 49.5 at $1.91 with Bet365
Today's 49ers vs Seahawks best bets are based on complex simulations and gambling expertise to help you place smarter bets with your chosen online bookie.
49ers vs Seahawks: Prediction
Stats Insider's predicted final score for 49ers vs Seahawks at Levi's Stadium in Week 18 is the Seahawks winning 24-23.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the San Francisco vs Seattle game in Week 18, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.49ers vs Seahawks: TD Scorer Tips
Who will score the first touchdown in 49ers vs Seahawks? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in 49ers vs Seahawks.
McCaffrey has a 16.7% chance of scoring the first TD at Levi's Stadium, while the 49ers RB has a 66.1% chance of scoring an anytime touchdown.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 16.7% probability
- Jauan Jennings: 7.6% probability
- George Kittle: 7.5% probability
- Ricky Pearsall: 4.0% probability
- Brock Purdy: 2.9% probability
Seahawks First TD Tips
- Jaxon Smith-Njigba: 10.6% probability
- Zach Charbonnet: 9.4% probability
- Kenneth Walker: 7.5% probability
- AJ Barner: 6.6% probability
- Rashid Shaheed: 5.3% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 66.1% probability
- Jauan Jennings: 38.7% probability
- George Kittle: 38.3% probability
- Ricky Pearsall: 22.8% probability
- Brock Purdy: 17.3% probability
Seahawks Anytime TD Tips
- Jaxon Smith-Njigba: 48.9% probability
- Zach Charbonnet: 45.1% probability
- Kenneth Walker: 38.0% probability
- AJ Barner: 34.4% probability
- Rashid Shaheed: 28.4% probability
49ers-Seahawks Projected Player Stats
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 248 passing yards. The Seahawks' Sam Darnold is expected to throw for 238 yards.
49ers Starting QB
- Brock Purdy: 248 projected passing yards
Seahawks Starting QB
- Sam Darnold: 238 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 70 projected yards
- Brock Purdy: 18 projected yards
- Brian Robinson: 15 projected yards
Seahawks Rushing Yards
- Kenneth Walker: 54 projected yards
- Zach Charbonnet: 45 projected yards
- Sam Darnold: 9 projected yards
49ers Receiving Yards
- George Kittle: 62 projected yards
- Jauan Jennings: 49 projected yards
- Ricky Pearsall: 48 projected yards
- Christian McCaffrey: 41 projected yards
- Demarcus Robinson: 12 projected yards
Seahawks Receiving Yards
- Jaxon Smith-Njigba: 104 projected yards
- Cooper Kupp: 43 projected yards
- Rashid Shaheed: 42 projected yards
- AJ Barner: 39 projected yards
- Kenneth Walker: 15 projected yards
Remember, our model updates frequently, so bookmark this article for the latest betting analysis before the San Francisco vs Seattle game.
As always, see Stats Insider's Best Bets to get the best tips for every NFL game, as well as predictions for a wide range of other sports.
49ers vs Seahawks: Week 18 Essential Details
The NFL Week 18 match-up between the 49ers and Seahawks at Levi's Stadium is scheduled to start at 12:00pm AEDT on Sunday.
- Teams: San Francisco 49ers vs Seattle Seahawks
- Date: Sunday 4 January 2026
- Time: 12:00pm AEDT
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our San Francisco vs Seattle predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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