49ers vs Rams Prediction and Preview - NFL Week 10, 2025
Last updated: Nov 3, 2025, 12:05PM | Published: Nov 2, 2025, 4:00AM
The San Francisco 49ers will take on the Los Angeles Rams in NFL Week 10 action at Levi's Stadium on Monday, commencing at 8:25am AEDT.
This article features Stats Insider's free betting tips for the 49ers vs Rams game, plus the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the result of Monday's San Francisco vs LA Rams NFL match-up 10,000 times.
Our independent predictive analytics model currently gives the 49ers a 56% chance of defeating the Rams at Levi's Stadium.
49ers vs Rams: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are listed below:
- Head to Head: 49ers $2.55, Rams $1.54
- Line: 49ers +3 ($1.91), Rams -3 ($1.91)
- Total (Over/Under 49 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $2.55 and the Rams at $1.54.
The 49ers are listed as 3-point underdogs against the Rams, with odds of $1.91 available at Bet365.
For the favourite Rams (-3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 49 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the 49ers (+3) are predicted to cover the line 69% of the time, while the 49-point over/under is expected to stay under 61% of the time.
49ers vs Rams: Best Bets
- Head to Head: San Francisco at $2.55 with Bet365
- Line: 49ers +3 at $1.91 with Bet365
- Total Points: Under 49 at $1.91 with Bet365
If you see a 🔥, that means you've found one of our best bets of the day across all sports.
Stats Insider's 49ers vs Rams best bets are based on detailed modelling and betting experience to give you the best possible advice around the clock.
49ers vs Rams: Prediction
Stats Insider's predicted final score for 49ers vs Rams at Levi's Stadium in Week 10 is the 49ers winning 23-22.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the San Francisco vs LA Rams game in Week 10, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.Remember, our model updates frequently, so keep checking this article for the latest betting tips before the San Francisco vs LA Rams game.
As always, see our Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.
49ers vs Rams: Week 10 Essential Details
The NFL Week 10 game between the 49ers and Rams at Levi's Stadium is scheduled to commence at 8:25am AEDT on Monday.
- Teams: San Francisco 49ers vs Los Angeles Rams
- Date: Monday 10 November 2025
- Time: 8:25am AEDT
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our San Francisco vs LA Rams predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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