49ers vs Rams Prediction and Preview - NFL Week 10, 2025
Last updated: Nov 9, 2025, 9:21PM | Published: Nov 2, 2025, 4:00AM
The San Francisco 49ers will face the favoured Los Angeles Rams in NFL Week 10 action at Levi's Stadium on Monday, commencing at 8:25am AEDT.
This article features Stats Insider's best betting tips for the 49ers vs Rams game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the result of Monday's San Francisco vs LA Rams NFL match-up 10,000 times.
Our proven predictive analytics model currently gives the Rams a 67% chance of defeating the 49ers in Week 10 of the NFL season.
49ers vs Rams: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are listed here:
- Head to Head: 49ers $3.20, Rams $1.37
- Line: 49ers +6 ($1.91), Rams -6 ($1.91)
- Total (Over/Under 49.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $3.20 and the Rams at $1.37.
The 49ers are listed as 6-point underdogs against the Rams, with odds of $1.91 available at Bet365.
For the favourite Rams (-6) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 49.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the 49ers (+6) are predicted to cover the line 57% of the time, while the 49.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
49ers vs Rams: Betting Tips
- Head to Head: San Francisco at $3.20 with Bet365
- Line: 49ers +6 at $1.91 with Bet365
- Total Points: Under 49.5 at $1.91 with Bet365
If you see a 🔥, that means it's one of Stats Insider's best bets of the day across any sport.
Stats Insider's 49ers vs Rams predictions are based on detailed modelling and wagering expertise to help you place better bets with your chosen online bookie.
While the Rams have a higher chance of winning the game, betting on the 49ers to win is our preferred option because of the 2.2% edge identified when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges published on Stats Insider is one of the keys to achieving long-term profitability.
49ers vs Rams: Prediction
Stats Insider's predicted final score for 49ers vs Rams at Levi's Stadium in Week 10 is the Rams winning 27-22.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the San Francisco vs LA Rams game in Week 10, including data-driven predictions and free tips.
For in-depth analysis from US experts,, check out Dimers' detailed 49ers vs Rams prediction.
18+. Odds correct at time of publishing and subject to change.49ers vs Rams: TD Scorer Tips
Who will score the first touchdown in 49ers vs Rams? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in 49ers vs Rams.
McCaffrey has a 15.0% chance of scoring the first TD at Levi's Stadium, while the 49ers RB has a 57.4% chance of scoring an anytime touchdown.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 15.0% probability
- George Kittle: 7.5% probability
- Jauan Jennings: 5.4% probability
- Kendrick Bourne: 3.4% probability
- Demarcus Robinson: 2.1% probability
Rams First TD Tips
- Kyren Williams: 12.1% probability
- Davante Adams: 11.8% probability
- Puka Nacua: 11.2% probability
- Tyler Higbee: 3.7% probability
- Blake Corum: 3.2% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 57.4% probability
- George Kittle: 34.6% probability
- Jauan Jennings: 26.4% probability
- Kendrick Bourne: 17.5% probability
- Demarcus Robinson: 11.2% probability
Rams Anytime TD Tips
- Kyren Williams: 51.4% probability
- Davante Adams: 50.5% probability
- Puka Nacua: 48.9% probability
- Tyler Higbee: 19.9% probability
- Blake Corum: 17.7% probability
49ers-Rams Projected Player Stats
Of the starting quarterbacks, the 49ers' Mac Jones is projected for 248 passing yards. The Rams' Matthew Stafford is expected to throw for 275 yards.
49ers Starting QB
- Mac Jones: 248 projected passing yards
Rams Starting QB
- Matthew Stafford: 275 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 69 projected yards
- Brian Robinson: 16 projected yards
- Mac Jones: 10 projected yards
Rams Rushing Yards
- Kyren Williams: 71 projected yards
- Blake Corum: 32 projected yards
- Matthew Stafford: 3 projected yards
49ers Receiving Yards
- Jauan Jennings: 54 projected yards
- George Kittle: 52 projected yards
- Christian McCaffrey: 49 projected yards
- Kendrick Bourne: 38 projected yards
- Demarcus Robinson: 21 projected yards
Rams Receiving Yards
- Puka Nacua: 97 projected yards
- Davante Adams: 65 projected yards
- Tyler Higbee: 25 projected yards
- Jordan Whittington: 24 projected yards
- Kyren Williams: 20 projected yards
Our model updates regularly, so keep checking this page for the latest betting predictions before the San Francisco vs LA Rams match-up.
As always, see Stats Insider's Best Bets for the best tips for every NFL game, as well as predictions for a wide range of other sports.
49ers vs Rams: Week 10 Essential Details
The NFL Week 10 game between the 49ers and Rams at Levi's Stadium is scheduled to commence at 8:25am AEDT on Monday.
- Teams: San Francisco 49ers vs Los Angeles Rams
- Date: Monday 10 November 2025
- Time: 8:25am AEDT
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our San Francisco vs LA Rams predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
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