49ers vs Panthers Prediction and Preview - NFL Week 12, 2025
Last updated: Nov 25, 2025, 3:57PM | Published: Nov 18, 2025, 5:01AM
The San Francisco 49ers will face the Carolina Panthers in NFL Week 12 action at Levi's Stadium on Tuesday, beginning at 12:15pm AEDT.
This article features Stats Insider's prediction and tips for the 49ers vs Panthers game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the result of Tuesday's San Francisco vs Carolina NFL game 10,000 times.
Our proven predictive analytics model currently gives the 49ers a 75% chance of winning against the Panthers in Week 12 of the NFL season.
49ers vs Panthers: Odds
The current Bet365 betting odds in Australia for Tuesday's NFL game at Levi's Stadium are shown below:
- Head to Head: 49ers $1.26, Panthers $4.00
- Line: 49ers -7.5 ($1.91), Panthers +7.5 ($1.91)
- Total (Over/Under 49.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.26 and the Panthers at $4.00.
The 49ers are listed as 7.5-point favourites against the Panthers, with odds of $1.91 available at Bet365.
For the underdog Panthers (+7.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 49.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the 49ers and the Panthers have a 50% chance of covering the line.
The 49.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
49ers vs Panthers: Best Bets
- Head to Head: Carolina at $4.00 with Bet365
- Line: Panthers +7.5 at $1.91 with Bet365
- Total Points: Under 49.5 at $1.91 with Bet365
Stats Insider's 49ers vs Panthers best bets are based on world-class simulations and betting experience to bring you the best possible advice 24/7.
While the 49ers have a higher chance of winning the game, betting on the Panthers to win is our recommended option because of the edge identified when comparing our data-led probabilities to the odds currently on offer.
Taking advantage of the edges seen here at Stats Insider is one of the keys to achieving long-term success as a sports bettor.
49ers vs Panthers: Prediction
Stats Insider's predicted final score for 49ers vs Panthers at Levi's Stadium in Week 12 is the 49ers winning 28-21.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the San Francisco vs Carolina game in Week 12, including data-driven predictions and live win probabilitiestips.
For in-depth analysis from US experts,, check out Dimers' detailed 49ers vs Panthers prediction.
18+. Odds correct at time of publishing and subject to change.49ers vs Panthers: TD Scorer Tips
Who will score an anytime touchdown in 49ers vs Panthers? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in 49ers vs Panthers.
McCaffrey has a 19.4% chance of getting in for six first at Levi's Stadium, while the 49ers RB has a 68.4% chance of registering an anytime touchdown.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 19.4% probability
- George Kittle: 9.1% probability
- Jauan Jennings: 6.4% probability
- Ricky Pearsall: 5.6% probability
- Brian Robinson: 3.7% probability
Panthers First TD Tips
- Rico Dowdle: 11.5% probability
- Tetairoa McMillan: 7.5% probability
- Xavier Legette: 3.9% probability
- Jalen Coker: 3.5% probability
- Ja'Tavion Sanders: 2.7% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 68.4% probability
- George Kittle: 41.9% probability
- Jauan Jennings: 31.8% probability
- Ricky Pearsall: 28.4% probability
- Brian Robinson: 19.9% probability
Panthers Anytime TD Tips
- Rico Dowdle: 48.2% probability
- Tetairoa McMillan: 34.8% probability
- Xavier Legette: 20.0% probability
- Jalen Coker: 18.0% probability
- Ja'Tavion Sanders: 14.1% probability
49ers-Panthers Projected Player Stats
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 256 passing yards. The Panthers' Bryce Young is expected to throw for 214 yards.
49ers Starting QB
- Brock Purdy: 256 projected passing yards
Panthers Starting QB
- Bryce Young: 214 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 69 projected yards
- Brian Robinson: 29 projected yards
- Brock Purdy: 14 projected yards
Panthers Rushing Yards
- Rico Dowdle: 77 projected yards
- Chuba Hubbard: 17 projected yards
- Bryce Young: 12 projected yards
49ers Receiving Yards
- George Kittle: 58 projected yards
- Jauan Jennings: 54 projected yards
- Ricky Pearsall: 49 projected yards
- Christian McCaffrey: 48 projected yards
- Demarcus Robinson: 18 projected yards
Panthers Receiving Yards
- Tetairoa McMillan: 71 projected yards
- Jalen Coker: 35 projected yards
- Xavier Legette: 31 projected yards
- Ja'Tavion Sanders: 24 projected yards
- Rico Dowdle: 21 projected yards
Remember, our model updates frequently, so refresh this page for the latest betting tips before the San Francisco vs Carolina game.
As always, see our Best Bets for the best tips for every NFL game, plus predictions for a wide range of other sports.
49ers vs Panthers: Week 12 Essential Details
The NFL Week 12 game between the 49ers and Panthers at Levi's Stadium is scheduled to commence at 12:15pm AEDT on Tuesday.
- Teams: San Francisco 49ers vs Carolina Panthers
- Date: Tuesday 25 November 2025
- Time: 12:15pm AEDT
- Venue: Levi's Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our San Francisco vs Carolina predictions have been made based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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