49ers vs Jaguars Prediction and Preview - NFL Week 4, 2025
Last updated: Sep 28, 2025, 8:05PM | Published: Sep 21, 2025, 4:02AM
The San Francisco 49ers will take on the Jacksonville Jaguars in NFL Week 4 action at Levi's Stadium on Monday, beginning at 6:05am AEST.
This article features Stats Insider's prediction and tips for the 49ers vs Jaguars game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Monday's San Francisco vs Jacksonville NFL match-up 10,000 times.
Our independent predictive analytics model currently gives the 49ers a 62% chance of beating the Jaguars at Levi's Stadium.
49ers vs Jaguars: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are shown here:
- Head to Head: 49ers $1.61, Jaguars $2.40
- Line: 49ers -3 ($1.91), Jaguars +3 ($1.91)
- Total (Over/Under 46 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.61 and the Jaguars at $2.40.
The 49ers are listed as 3-point favourites against the Jaguars, with odds of $1.91 available at Bet365.
For the underdog Jaguars (+3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 46 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the 49ers (-3) are predicted to cover the line 57% of the time, while the 46-point over/under is expected to stay under 51% of the time.
49ers vs Jaguars: Best Bets
- Head to Head: San Francisco at $1.61 with Bet365
- Line: 49ers -3 at $1.91 with Bet365
- Total Points: Under 46 at $1.91 with Bet365
When you see a 🔥, you know it's one of our best bets of the day across all sports.
Stats Insider's 49ers vs Jaguars predictions are based on market-leading modelling and gambling expertise to give you the best possible advice every day of the year.
49ers vs Jaguars: Prediction
Stats Insider's predicted final score for 49ers vs Jaguars at Levi's Stadium in Week 4 is the 49ers prevailing 24-21.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the San Francisco vs Jacksonville game in Week 4, including data-driven predictions and free tips.
Get expert analysis from the US with Dimers' in-depth 49ers vs Jaguars prediction.
18+. Odds correct at time of publishing and subject to change.49ers vs Jaguars: TD Scorer Tips
Who will score the first touchdown in 49ers vs Jaguars? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in 49ers vs Jaguars.
McCaffrey has a 16.8% chance of scoring the first TD at Levi's Stadium, while the 49ers RB has a 58.6% chance of reaching the end zone at any point during the game.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 16.8% probability
- Ricky Pearsall: 7.2% probability
- Jauan Jennings: 6.7% probability
- Brian Robinson: 4.0% probability
- Brock Purdy: 3.3% probability
Jaguars First TD Tips
- Travis Etienne: 8.7% probability
- Brian Thomas: 8.1% probability
- Bhayshul Tuten: 5.4% probability
- Parker Washington: 4.5% probability
- Travis Hunter: 4.4% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 58.6% probability
- Ricky Pearsall: 31.4% probability
- Jauan Jennings: 29.7% probability
- Brian Robinson: 18.9% probability
- Brock Purdy: 16.0% probability
Jaguars Anytime TD Tips
- Travis Etienne: 35.5% probability
- Brian Thomas: 33.7% probability
- Bhayshul Tuten: 23.9% probability
- Parker Washington: 20.5% probability
- Travis Hunter: 19.8% probability
49ers-Jaguars Projected Player Stats
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 247 passing yards. The Jaguars' Trevor Lawrence is expected to throw for 233 yards.
49ers Starting QB
- Brock Purdy: 247 projected passing yards
Jaguars Starting QB
- Trevor Lawrence: 233 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 79 projected yards
- Brian Robinson: 23 projected yards
- Brock Purdy: 16 projected yards
Jaguars Rushing Yards
- Travis Etienne: 54 projected yards
- Bhayshul Tuten: 26 projected yards
- Trevor Lawrence: 14 projected yards
49ers Receiving Yards
- Ricky Pearsall: 65 projected yards
- Jauan Jennings: 47 projected yards
- Christian McCaffrey: 45 projected yards
- Jake Tonges: 25 projected yards
- Kendrick Bourne: 22 projected yards
Jaguars Receiving Yards
- Brian Thomas: 63 projected yards
- Parker Washington: 42 projected yards
- Travis Hunter: 38 projected yards
- Brenton Strange: 36 projected yards
- Travis Etienne: 17 projected yards
Remember, our model updates frequently, so refresh this page for the latest betting analysis before the San Francisco vs Jacksonville game.
As always, see our Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.
49ers vs Jaguars: Week 4 Essential Details
The NFL Week 4 match-up between the 49ers and Jaguars at Levi's Stadium is scheduled to begin at 6:05am AEST on Monday.
- Teams: San Francisco 49ers vs Jacksonville Jaguars
- Date: Monday 29 September 2025
- Time: 6:05am AEST
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our San Francisco vs Jacksonville predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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