49ers vs Dolphins Prediction and Preview - NFL Week 2, 2026
Last updated: Sep 20, 2026, 8:20PM | Published: Sep 13, 2026, 4:01AM
The San Francisco 49ers will take on the Miami Dolphins in NFL Week 2 action at Levi's Stadium on Monday, beginning at 6:25am AEST.
This article features Stats Insider's free betting tips for the 49ers vs Dolphins game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the outcome of Monday's San Francisco vs Miami NFL game 10,000 times.
Our leading predictive analytics model gives the 49ers an 87% chance of defeating the Dolphins in Week 2 of the NFL season.
49ers vs Dolphins: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are shown below:
- Head to Head: 49ers $1.10, Dolphins $7.25
- Line: 49ers -13.5 ($1.91), Dolphins +13.5 ($1.91)
- Total (Over/Under 44.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.10 and the Dolphins at $7.25.
The 49ers are 13.5-point favourites against the Dolphins, with odds of $1.91 available at Bet365.
For the underdog Dolphins (+13.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 44.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Dolphins (+13.5) are predicted to cover the line 51% of the time, while the 44.5-point over/under is expected to stay under 51% of the time.
49ers vs Dolphins: Best Bets
- Head to Head: Miami at $7.25 with Bet365
- Line: Dolphins +13.5 at $1.91 with Bet365
- Total Points: Under 44.5 at $1.91 with Bet365
These 49ers vs Dolphins betting tips are based on detailed simulations and betting intelligence to help you place smarter bets with your chosen online bookie.
While the 49ers have a higher chance of winning the game, betting on the Dolphins to win is our recommended option because of the edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges published on Stats Insider is crucial to being profitable in the long run.
49ers vs Dolphins: Prediction
Stats Insider's predicted final score for 49ers vs Dolphins at Levi's Stadium in Week 2 is the 49ers winning 28-15.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the San Francisco vs Miami game in Week 2, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.49ers vs Dolphins: TD Scorer Tips
Who will score an anytime touchdown in 49ers vs Dolphins? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in 49ers vs Dolphins.
McCaffrey has a 17.4% chance of getting in for six first at Levi's Stadium, while the 49ers RB has a 60.4% chance of reaching the end zone at any point in the game.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 17.4% probability
- Mike Evans: 9.2% probability
- George Kittle: 7.2% probability
- Deebo Samuel: 6.3% probability
- Kaelon Black: 5.4% probability
Dolphins First TD Tips
- De'Von Achane: 10.1% probability
- Malik Willis: 5.2% probability
- Caleb Douglas: 4.0% probability
- Malik Washington: 4.0% probability
- Chris Bell: 2.9% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 60.4% probability
- Mike Evans: 38.9% probability
- George Kittle: 31.9% probability
- Deebo Samuel: 28.4% probability
- Kaelon Black: 25.1% probability
Dolphins Anytime TD Tips
- De'Von Achane: 43.2% probability
- Malik Willis: 25.1% probability
- Caleb Douglas: 20.3% probability
- Malik Washington: 19.9% probability
- Chris Bell: 14.9% probability
49ers-Dolphins Projected Player Stats
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 233 passing yards, while the Dolphins' Malik Willis is expected to throw for 193 yards.
49ers Starting QB
- Brock Purdy: 233 projected passing yards
Dolphins Starting QB
- Malik Willis: 193 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 64 projected yards
- Kaelon Black: 41 projected yards
- Brock Purdy: 16 projected yards
Dolphins Rushing Yards
- De'Von Achane: 64 projected yards
- Malik Willis: 44 projected yards
- Jaylen Wright: 10 projected yards
49ers Receiving Yards
- Mike Evans: 55 projected yards
- George Kittle: 43 projected yards
- Deebo Samuel: 41 projected yards
- Christian McCaffrey: 40 projected yards
- Demarcus Robinson: 32 projected yards
Dolphins Receiving Yards
- Caleb Douglas: 43 projected yards
- Malik Washington: 40 projected yards
- De'Von Achane: 29 projected yards
- Chris Bell: 26 projected yards
- Greg Dulcich: 25 projected yards
Our model updates frequently, so refresh this page for the latest betting predictions before the San Francisco vs Miami game.
As always, see our Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.
49ers vs Dolphins: Week 2 Essential Details
The NFL Week 2 match-up between the 49ers and Dolphins at Levi's Stadium is scheduled to commence at 6:25am AEST on Monday.
- Teams: San Francisco 49ers vs Miami Dolphins
- Date: Monday 21 September 2026
- Time: 6:25am AEST
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our San Francisco vs Miami predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on NFL
Stats Insider is your go-to source for betting on the NFL in Australia, with the latest NFL betting news, predictions for every NFL game, and Super Bowl odds for the NFL.
