49ers vs Cardinals Prediction and Preview - NFL Week 3, 2026
Last updated: Sep 27, 2026, 8:05PM | Published: Sep 20, 2026, 4:01AM
The San Francisco 49ers will face the Arizona Cardinals in NFL Week 3 action at Levi's Stadium on Monday, beginning at 6:05am AEST.
This article features Stats Insider's best betting tips for the 49ers vs Cardinals game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the outcome of Monday's San Francisco vs Arizona NFL game 10,000 times.
Our leading predictive analytics model currently gives the 49ers a 76% chance of beating the Cardinals at Levi's Stadium.
49ers vs Cardinals: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are shown below:
- Head to Head: 49ers $1.26, Cardinals $4.10
- Line: 49ers -7.5 ($1.91), Cardinals +7.5 ($1.91)
- Total (Over/Under 48.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.26 and the Cardinals at $4.10.
The 49ers are listed as 7.5-point favourites against the Cardinals, with odds of $1.91 available at Bet365.
For the underdog Cardinals (+7.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the 49ers (-7.5) are predicted to cover the line 53% of the time, while the 48.5-point over/under is expected to stay under 51% of the time.
49ers vs Cardinals: Betting Tips
- Head to Head: Arizona at $4.10 with Bet365
- Line: 49ers -7.5 at $1.91 with Bet365
- Total Points: Under 48.5 at $1.91 with Bet365
Today's 49ers vs Cardinals best bets are based on detailed simulations and betting experience to help you place smarter bets with your chosen online bookie.
While the 49ers have a higher chance of winning the game, betting on the Cardinals to win is our recommended option due to the edge identified when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges published on Stats Insider is pivotal to achieving long-term profitability.
49ers vs Cardinals: Prediction
Stats Insider's predicted final score for 49ers vs Cardinals at Levi's Stadium in Week 3 is the 49ers winning 28-19.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the San Francisco vs Arizona game in Week 3, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.49ers vs Cardinals: TD Scorer Tips
Who will score an anytime touchdown in 49ers vs Cardinals? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in 49ers vs Cardinals.
McCaffrey has a 16.4% chance of scoring the first TD at Levi's Stadium, while the 49ers RB has a 61.5% chance of scoring an anytime touchdown.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 16.4% probability
- Mike Evans: 8.1% probability
- George Kittle: 7.2% probability
- Deebo Samuel: 6.3% probability
- Brock Purdy: 4.4% probability
Cardinals First TD Tips
- Jeremiyah Love: 9.5% probability
- Trey McBride: 8.3% probability
- Tyler Allgeier: 6.3% probability
- Michael Wilson: 6.0% probability
- Marvin Harrison: 4.1% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 61.5% probability
- Mike Evans: 37.6% probability
- George Kittle: 34.1% probability
- Deebo Samuel: 30.7% probability
- Brock Purdy: 22.4% probability
Cardinals Anytime TD Tips
- Jeremiyah Love: 39.4% probability
- Trey McBride: 35.6% probability
- Tyler Allgeier: 28.4% probability
- Michael Wilson: 27.2% probability
- Marvin Harrison: 19.4% probability
49ers-Cardinals Projected Player Stats
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 241 passing yards. The Cardinals' Jacoby Brissett is expected to throw for 233 yards.
49ers Starting QB
- Brock Purdy: 241 projected passing yards
Cardinals Starting QB
- Jacoby Brissett: 233 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 64 projected yards
- Kaelon Black: 33 projected yards
- Brock Purdy: 21 projected yards
Cardinals Rushing Yards
- Jeremiyah Love: 46 projected yards
- Tyler Allgeier: 36 projected yards
- Jacoby Brissett: 12 projected yards
49ers Receiving Yards
- Mike Evans: 58 projected yards
- George Kittle: 49 projected yards
- Deebo Samuel: 46 projected yards
- Christian McCaffrey: 40 projected yards
- Jacob Cowing: 13 projected yards
Cardinals Receiving Yards
- Trey McBride: 69 projected yards
- Michael Wilson: 52 projected yards
- Marvin Harrison: 38 projected yards
- Kendrick Bourne: 30 projected yards
- Jeremiyah Love: 19 projected yards
Remember, our model updates frequently, so keep checking this article for the latest betting predictions before the San Francisco vs Arizona game.
As always, see Stats Insider's Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
49ers vs Cardinals: Week 3 Essential Details
The NFL Week 3 game between the 49ers and Cardinals at Levi's Stadium is scheduled to start at 6:05am AEST on Monday.
- Teams: San Francisco 49ers vs Arizona Cardinals
- Date: Monday 28 September 2026
- Time: 6:05am AEST
- Venue: Levi's Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our San Francisco vs Arizona predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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