49ers vs Cardinals Prediction and Preview - NFL Week 3, 2025
Last updated: Sep 21, 2025, 8:20PM | Published: Sep 17, 2025, 8:23PM
The San Francisco 49ers will face the Arizona Cardinals in NFL Week 3 action at Levi's Stadium on Monday, beginning at 6:25am AEST.
This article features Stats Insider's prediction and tips for the 49ers vs Cardinals game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the result of Monday's San Francisco vs Arizona NFL game 10,000 times.
Our proven predictive analytics model gives the 49ers a 56% chance of defeating the Cardinals in Week 3 of the NFL season.
49ers vs Cardinals: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are shown here:
- Head to Head: 49ers $1.80, Cardinals $2.05
- Line: 49ers -1.5 ($1.91), Cardinals +1.5 ($1.91)
- Total (Over/Under 44.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.80 and the Cardinals at $2.05.
The 49ers are listed as 1.5-point favourites against the Cardinals, with odds of $1.91 available at Bet365.
For the underdog Cardinals (+1.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 44.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the 49ers and the Cardinals have a 50% chance of covering the line.
The 44.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
49ers vs Cardinals: Best Bets
- Head to Head: San Francisco at $1.80 with Bet365
- Line: Cardinals +1.5 at $1.91 with Bet365
- Total Points: Under 44.5 at $1.91 with Bet365
These 49ers vs Cardinals best bets are based on detailed modelling and wagering intelligence to give you the best possible advice 24/7.
49ers vs Cardinals: Prediction
Stats Insider's predicted final score for 49ers vs Cardinals at Levi's Stadium in Week 3 is the 49ers winning 23-21.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the San Francisco vs Arizona game in Week 3, including data-driven predictions and expert tips.
Get expert analysis from the US with Dimers' in-depth 49ers vs Cardinals prediction.
18+. Odds correct at time of publishing and subject to change.49ers vs Cardinals: TD Scorer Tips
Who will score the first touchdown in 49ers vs Cardinals? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in 49ers vs Cardinals.
McCaffrey has a 17.4% chance of scoring the first TD at Levi's Stadium, while the 49ers RB has a 57.2% chance of scoring an anytime touchdown.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 17.4% probability
- Ricky Pearsall: 7.2% probability
- Brian Robinson: 4.4% probability
- Kendrick Bourne: 4.3% probability
- Jake Tonges: 3.2% probability
Cardinals First TD Tips
- James Conner: 12.2% probability
- Marvin Harrison: 7.8% probability
- Trey McBride: 6.5% probability
- Kyler Murray: 5.1% probability
- Trey Benson: 4.8% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 57.2% probability
- Ricky Pearsall: 29.5% probability
- Brian Robinson: 19.4% probability
- Kendrick Bourne: 18.9% probability
- Jake Tonges: 14.6% probability
Cardinals Anytime TD Tips
- James Conner: 45.8% probability
- Marvin Harrison: 32.6% probability
- Trey McBride: 28.1% probability
- Kyler Murray: 22.6% probability
- Trey Benson: 21.6% probability
49ers-Cardinals Projected Player Stats
Of the starting quarterbacks, the 49ers' Mac Jones is projected for 221 passing yards, while the Cardinals' Kyler Murray is expected to throw for 220 yards.
49ers Starting QB
- Mac Jones: 221 projected passing yards
Cardinals Starting QB
- Kyler Murray: 220 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 80 projected yards
- Brian Robinson: 24 projected yards
- Mac Jones: 11 projected yards
Cardinals Rushing Yards
- James Conner: 56 projected yards
- Kyler Murray: 33 projected yards
- Trey Benson: 30 projected yards
49ers Receiving Yards
- Ricky Pearsall: 70 projected yards
- Christian McCaffrey: 41 projected yards
- Kendrick Bourne: 36 projected yards
- Jake Tonges: 26 projected yards
- Marquez Valdes-Scantling: 20 projected yards
Cardinals Receiving Yards
- Trey McBride: 63 projected yards
- Marvin Harrison: 55 projected yards
- Michael Wilson: 31 projected yards
- James Conner: 17 projected yards
- Trey Benson: 12 projected yards
Our model updates frequently, so bookmark this page for the latest betting tips before the San Francisco vs Arizona game.
As always, see Stats Insider's Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.
49ers vs Cardinals: Week 3 Essential Details
The NFL Week 3 match-up between the 49ers and Cardinals at Levi's Stadium is scheduled to begin at 6:25am AEST on Monday.
- Teams: San Francisco 49ers vs Arizona Cardinals
- Date: Monday 22 September 2025
- Time: 6:25am AEST
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our San Francisco vs Arizona predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on NFL
Stats Insider is your home for betting on the NFL in Australia, with the latest NFL betting news, tips for every NFL game, and Super Bowl probabilities for the NFL.
