49ers vs Cardinals Prediction and Preview - NFL Week 3, 2025
Last updated: Sep 15, 2025, 8:35AM | Published: Sep 14, 2025, 4:01AM
The San Francisco 49ers will take on the Arizona Cardinals in NFL Week 3 action at Levi's Stadium on Monday, commencing at 6:25am AEST.
This article features Stats Insider's prediction and tips for the 49ers vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the outcome of Monday's San Francisco vs Arizona NFL match-up 10,000 times.
Our leading predictive analytics model gives the 49ers a 61% chance of beating the Cardinals at Levi's Stadium.
49ers vs Cardinals: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are shown here:
- Head to Head: 49ers $1.91, Cardinals $1.91
- Line: 49ers +1 ($1.91), Cardinals -1 ($1.91)
- Total (Over/Under 43.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.91 and the Cardinals at $1.91.
The 49ers are listed as 1-point underdogs against the Cardinals, with odds of $1.91 available at Bet365.
For the favourite Cardinals (-1) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 43.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the 49ers (+1) are predicted to cover the line 74% of the time, while the 43.5-point over/under is expected to go over 62% of the time.
49ers vs Cardinals: Betting Tips
- Head to Head: San Francisco at $1.91 with Bet365
- Line: 49ers +1 at $1.91 with Bet365
- Total Points: Over 43.5 at $1.91 with Bet365
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Our 49ers vs Cardinals betting tips are based on detailed modelling and wagering intelligence to help you place smarter bets with your chosen online bookie.
49ers vs Cardinals: Prediction
Stats Insider's predicted final score for 49ers vs Cardinals at Levi's Stadium in Week 3 is the 49ers winning 25-21.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the San Francisco vs Arizona game in Week 3, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.Our model updates regularly, so refresh this page for the latest betting analysis before the San Francisco vs Arizona game.
As always, see our Best Bets for betting tips for every NFL game, plus predictions for a wide range of other sports.
49ers vs Cardinals: Week 3 Essential Details
The NFL Week 3 game between the 49ers and Cardinals at Levi's Stadium is scheduled to begin at 6:25am AEST on Monday.
- Teams: San Francisco 49ers vs Arizona Cardinals
- Date: Monday 22 September 2025
- Time: 6:25am AEST
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our San Francisco vs Arizona predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's vital to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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