49ers vs Broncos Prediction and Preview - NFL Week 4, 2026
Last updated: Sep 30, 2026, 12:32AM | Published: Sep 27, 2026, 4:02AM
The San Francisco 49ers will face the Denver Broncos in NFL Week 4 action at Levi's Stadium on Monday, beginning at 7:25am AEDT.
This article features Stats Insider's free betting tips for the 49ers vs Broncos game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Monday's San Francisco vs Denver NFL match-up 10,000 times.
Our leading predictive analytics model gives the 49ers a 63% chance of beating the Broncos at Levi's Stadium.
49ers vs Broncos: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Levi's Stadium are shown below:
- Head to Head: 49ers $1.64, Broncos $2.30
- Line: 49ers -2.5 ($1.91), Broncos +2.5 ($1.91)
- Total (Over/Under 47.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.64 and the Broncos at $2.30.
The 49ers are listed as 2.5-point favourites against the Broncos, with odds of $1.91 available at Bet365.
For the underdog Broncos (+2.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the 49ers (-2.5) are predicted to cover the line 59% of the time, while the 47.5-point over/under is expected to stay under 51% of the time.
49ers vs Broncos: Betting Tips
- Head to Head: San Francisco at $1.64 with Bet365
- Line: 49ers -2.5 at $1.91 with Bet365
- Total Points: Under 47.5 at $1.91 with Bet365
When you see a 🔥, that means it's one of our best bets of the day across all sports.
Today's 49ers vs Broncos best bets are based on world-class modelling and gambling expertise to help you place smarter bets with your chosen online bookie.
49ers vs Broncos: Prediction
Stats Insider's predicted final score for 49ers vs Broncos at Levi's Stadium in Week 4 is the 49ers winning 25-21.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the San Francisco vs Denver game in Week 4, including data-driven predictions and live win probabilitiestips.
18+. Odds correct at time of publishing and subject to change.49ers vs Broncos: TD Scorer Tips
Who will score an anytime touchdown in 49ers vs Broncos? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in 49ers vs Broncos.
McCaffrey has a 14.8% chance of scoring the first TD at Levi's Stadium, while the 49ers RB has a 54.8% chance of scoring an anytime touchdown.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
49ers First TD Tips
- Christian McCaffrey: 14.8% probability
- Mike Evans: 9.7% probability
- George Kittle: 7.5% probability
- Brock Purdy: 4.4% probability
- Deebo Samuel: 4.2% probability
Broncos First TD Tips
- RJ Harvey: 9.0% probability
- Courtland Sutton: 6.1% probability
- J.K. Dobbins: 4.8% probability
- Bo Nix: 4.3% probability
- Pat Bryant: 4.3% probability
Anytime Touchdown Scorer Tips
49ers Anytime TD Tips
- Christian McCaffrey: 54.8% probability
- Mike Evans: 40.5% probability
- George Kittle: 33.0% probability
- Brock Purdy: 21.2% probability
- Deebo Samuel: 20.4% probability
Broncos Anytime TD Tips
- RJ Harvey: 40.1% probability
- Courtland Sutton: 29.5% probability
- J.K. Dobbins: 24.1% probability
- Bo Nix: 21.8% probability
- Pat Bryant: 21.8% probability
49ers-Broncos Projected Player Stats
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 229 passing yards, while the Broncos' Bo Nix is expected to throw for 232 yards.
49ers Starting QB
- Brock Purdy: 229 projected passing yards
Broncos Starting QB
- Bo Nix: 232 projected passing yards
49ers Rushing Yards
- Christian McCaffrey: 66 projected yards
- Kaelon Black: 28 projected yards
- Brock Purdy: 20 projected yards
Broncos Rushing Yards
- J.K. Dobbins: 59 projected yards
- RJ Harvey: 31 projected yards
- Bo Nix: 22 projected yards
49ers Receiving Yards
- George Kittle: 59 projected yards
- Mike Evans: 56 projected yards
- Christian McCaffrey: 39 projected yards
- Deebo Samuel: 36 projected yards
- Jacob Cowing: 12 projected yards
Broncos Receiving Yards
- Jaylen Waddle: 60 projected yards
- Courtland Sutton: 43 projected yards
- Pat Bryant: 28 projected yards
- RJ Harvey: 25 projected yards
- Evan Engram: 23 projected yards
Remember, our model updates frequently, so refresh this article for the latest betting predictions before the San Francisco vs Denver match-up.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.
49ers vs Broncos: Week 4 Essential Details
The NFL Week 4 match-up between the 49ers and Broncos at Levi's Stadium is scheduled to start at 7:25am AEDT on Monday.
- Teams: San Francisco 49ers vs Denver Broncos
- Date: Monday 5 October 2026
- Time: 7:25am AEDT
- Venue: Levi's Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our San Francisco vs Denver predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's important that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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