49ers vs Bears Prediction and Preview - NFL Week 17, 2025
Last updated: Dec 22, 2025, 8:00AM | Published: Dec 22, 2025, 5:00AM
The San Francisco 49ers will face the Chicago Bears in NFL Week 17 action at Levi's Stadium on Monday, December 29, commencing at 12:20pm AEDT.
This article features Stats Insider's prediction and tips for the 49ers vs Bears game, plus the latest betting odds in Australia.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the outcome of Bears vs 49ers 10,000 times.
Our leading predictive analytics model currently gives the 49ers a 60% chance of beating the Bears at Levi's Stadium.
49ers vs Bears: Odds
The current Bet365 betting odds in Australia for this NFL game at Levi's Stadium are shown here:
- Head to Head: 49ers $1.67, Bears $2.25
- Line: 49ers -2.5 ($1.91), Bears +2.5 ($1.91)
- Total (Over/Under 50.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the 49ers at $1.67 and the Bears at $2.25.
The 49ers are 2.5-point favourites against the Bears, with odds of $1.91 available at Bet365.
For the underdog Bears (+2.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 50.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the 49ers (-2.5) are predicted to cover the line 57% of the time, while the 50.5-point over/under is expected to stay under 53% of the time.
49ers vs Bears: Best Bets
- Head to Head: San Francisco at $1.67 with Bet365
- Line: 49ers -2.5 at $1.91 with Bet365
- Total Points: Under 50.5 at $1.91 with Bet365
When you see a 🔥, you know you've found one of our best bets for today across any sport.
These 49ers vs Bears best bets are based on market-leading simulations and wagering intelligence to help you place smarter bets with your chosen online bookie.
49ers vs Bears: Prediction
Stats Insider's predicted final score for 49ers vs Bears at Levi's Stadium in Week 17 is the 49ers winning 26-23.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the San Francisco vs Chicago game in Week 17, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.Our model updates regularly, so keep checking this page for the latest betting tips before the San Francisco vs Chicago game.
As always, see Stats Insider's Best Bets for the best tips on every NFL game, plus predictions for a wide range of other sports.
49ers vs Bears: Week 17 Essential Details
The NFL Week 17 match-up between the 49ers and Bears at Levi's Stadium is scheduled to start at 12:20pm AEDT on Monday, December 29.
- Teams: San Francisco 49ers vs Chicago Bears
- Date: Monday 29 December 2025
- Time: 12:20pm AEDT
- Venue: Levi's Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our San Francisco vs Chicago predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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