Bills vs Buccaneers Prediction and Preview - NFL Week 11, 2025
Last updated: Nov 16, 2025, 5:55PM | Published: Nov 9, 2025, 5:01AM
The Buffalo Bills will take on the Tampa Bay Buccaneers in NFL Week 11 action at Highmark Stadium on Monday, starting at 5:00am AEDT.
This article features Stats Insider's prediction and tips for the Bills vs Buccaneers game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the outcome of Monday's Buffalo vs Tampa Bay NFL game 10,000 times.
Our proven predictive analytics model currently gives the Bills a 72% chance of winning against the Buccaneers in Week 11 of the NFL season.
Bills vs Buccaneers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Highmark Stadium are listed here:
- Head to Head: Bills $1.33, Buccaneers $3.40
- Line: Bills -6.5 ($1.91), Buccaneers +6.5 ($1.91)
- Total (Over/Under 45.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Bills at $1.33 and the Buccaneers at $3.40.
The Bills are listed as 6.5-point favourites against the Buccaneers, with odds of $1.91 available at Bet365.
For the underdog Buccaneers (+6.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 45.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Bills and the Buccaneers have a 50% chance of covering the line.
The 45.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
Bills vs Buccaneers: Best Bets
- Head to Head: Tampa Bay at $3.40 with Bet365
- Line: Buccaneers +6.5 at $1.91 with Bet365
- Total Points: Under 45.5 at $1.91 with Bet365
Today's Bills vs Buccaneers betting tips are based on world-class simulations and betting experience to help you place smarter bets with your chosen online bookie.
While the Bills have a higher chance of winning the game, betting on the Buccaneers to win is our recommended option due to the edge identified when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges published on Stats Insider is pivotal to being profitable in the long run.
Bills vs Buccaneers: Prediction
Stats Insider's predicted final score for Bills vs Buccaneers at Highmark Stadium in Week 11 is the Bills winning 26-19.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the Buffalo vs Tampa Bay game in Week 11, including data-driven predictions and top betting tips.
Get expert analysis from the US with Dimers' in-depth Bills vs Buccaneers prediction.
18+. Odds correct at time of publishing and subject to change.Bills vs Buccaneers: TD Scorer Tips
Who will score the first touchdown in Bills vs Buccaneers? The data is in.
According to Stats Insider, Buffalo's James Cook is the most likely player to score the first TD in Bills vs Buccaneers.
Cook has a 13.4% chance of scoring the first TD at Highmark Stadium, while the Bills RB has a 54.9% chance of reaching the end zone at any point during the game.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Bills First TD Tips
- James Cook: 13.4% probability
- Josh Allen: 10.6% probability
- Khalil Shakir: 5.7% probability
- Dawson Knox: 4.1% probability
- Joshua Palmer: 3.4% probability
Buccaneers First TD Tips
- Rachaad White: 8.8% probability
- Emeka Egbuka: 8.2% probability
- Sean Tucker: 5.6% probability
- Tez Johnson: 5.3% probability
- Cade Otton: 4.4% probability
Anytime Touchdown Scorer Tips
Bills Anytime TD Tips
- James Cook: 54.9% probability
- Josh Allen: 46.8% probability
- Khalil Shakir: 28.7% probability
- Dawson Knox: 21.4% probability
- Joshua Palmer: 18.4% probability
Buccaneers Anytime TD Tips
- Rachaad White: 39.9% probability
- Emeka Egbuka: 37.8% probability
- Sean Tucker: 27.4% probability
- Tez Johnson: 26.5% probability
- Cade Otton: 22.3% probability
Bills-Buccaneers Projected Player Stats
Of the starting quarterbacks, the Bills' Josh Allen is projected for 225 passing yards. The Buccaneers' Baker Mayfield is expected to throw for 217 yards.
Bills Starting QB
- Josh Allen: 225 projected passing yards
Buccaneers Starting QB
- Baker Mayfield: 217 projected passing yards
Bills Rushing Yards
- James Cook: 86 projected yards
- Josh Allen: 32 projected yards
- Ty Johnson: 13 projected yards
Buccaneers Rushing Yards
- Rachaad White: 49 projected yards
- Sean Tucker: 40 projected yards
- Baker Mayfield: 20 projected yards
Bills Receiving Yards
- Khalil Shakir: 55 projected yards
- Joshua Palmer: 36 projected yards
- Dawson Knox: 29 projected yards
- Tyrell Shavers: 17 projected yards
- Curtis Samuel: 16 projected yards
Buccaneers Receiving Yards
- Emeka Egbuka: 63 projected yards
- Cade Otton: 40 projected yards
- Tez Johnson: 38 projected yards
- Sterling Shepard: 26 projected yards
- Rachaad White: 20 projected yards
Our model updates frequently, so refresh this article for the latest betting predictions before the Buffalo vs Tampa Bay game.
As always, see our Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
Bills vs Buccaneers: Week 11 Essential Details
The NFL Week 11 game between the Bills and Buccaneers at Highmark Stadium is scheduled to commence at 5:00am AEDT on Monday.
- Teams: Buffalo Bills vs Tampa Bay Buccaneers
- Date: Monday 17 November 2025
- Time: 5:00am AEDT
- Venue: Highmark Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Buffalo vs Tampa Bay predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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